B6CBA-Tg(S100A8-PML/RARA)15Hdt/Orl
| Status | Available to order |
| EMMA ID | EM:05184 |
| Citation information | RRID:IMSR_EM:05184 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6CBA-Tg(S100A8-PML/RARA)15Hdt/Orl |
| Alternative name | PML-RARa wt 15 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(S100A8-PML/RARA)15Hdt |
| Gene/Transgene symbol | Tg(S100A8-PML/RARA)15Hdt |
Information from provider
| Provider | Hugues De The |
| Provider affiliation | UMR7212 / U944, Université Paris VII - CNRS/ INSERM |
| Genetic information | PML-RARalpha wild-type transgenic mice. PML-RARa is the chromosomal translocation responsible for Acute Promyelocytic Leukemia. |
| Phenotypic information | Leukemic phenotype. |
| Breeding history | Crossed on B6CBA background for 6 generations. Heterozygous crossing always performed. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6.CBA males, wild-type C57BL/6.CBA females |
| Breeding at archiving centre | transgenic males |
Literature references
- A sumoylation site in PML/RARA is essential for leukemic transformation.;Zhu Jun, Zhou Jun, Peres Laurent, Riaucoux Florence, Honoré Nicole, Kogan Scott, de Thé Hugues, ;2005;Cancer cell;7;143-53; 15710327