MGI phenotypes (allele matching)
129-Ctsgtm1.1Roes/H
| Status | Available to order |
| EMMA ID | EM:00052 |
| Citation information | RRID:IMSR_EM:00052 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129-Ctsgtm1.1Roes/H |
| Alternative name | CG-/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ctsgtm1.1Roes |
| Gene/Transgene symbol | Ctsg |
Information from provider
| Provider | Jurgen Roes |
| Provider affiliation | Windeyer Institute of Medical Sciences, University College London |
| Genetic information | This knockout was created by cre/loxP-mediated deletion of exons 2, 3 and part of exon 4 in ES cells. |
| Phenotypic information | Mice deficient in Ctsg are susceptible to fungal infections, despite normal neutrophil development and recruitment. |
| Breeding history | inbred on 129P2 and 129S2. |
| References |
|
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased leukocyte cell number / MGI
- extramedullary hematopoiesis / MGI
- enlarged liver / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- anemia / MGI
- abnormal myelopoiesis / MGI
- neoplasm / MGI
- increased leukemia incidence / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- abnormal bone marrow cell morphology/development / MGI
- thrombocytopenia / MGI
- increased acute promyelocytic leukemia incidence / MGI
- increased spleen weight / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
Literature references
- Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.;Tkalcevic J, Novelli M, Phylactides M, Iredale J P, Segal A W, Roes J, ;2000;Immunity;12;201-10; 10714686
- Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice.;Hahn Ines, Klaus Anna, Janze Ann-Kathrin, Steinwede Kathrin, Ding Nadine, Bohling Jennifer, Brumshagen Christina, Serrano Hélène, Gauthier Francis, Paton James C, Welte Tobias, Maus Ulrich A, ;2011;Infection and immunity;79;4893-901; 21911460
- Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis.;Aghdassi Ali A, John Daniel S, Sendler Matthias, Storck Christian, van den Brandt Cindy, Krüger Burkhard, Weiss Frank Ulrich, Mayerle Julia, Lerch Markus M, ;2019;Scientific reports;9;16774; 31727956