| Status | Available to order |
| EMMA ID | EM:05204 |
| Citation information | RRID:IMSR_EM:05204 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6NHsd.129S7-Prnptm1Cwe/OrlIeg |
| Alternative name | B6-prnp (N20 PrP B6NHsd/CweOrl |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Prnptm1Cwe |
| Gene/Transgene symbol | Prnp |
| Provider | Jörg Kirberg |
| Provider affiliation | N/A |
| Additional owner | Charles Weissmann, Universitaet Zuerich, Zuerich, Switzerland Ulrich Kalinke, Paul-Ehrlich-Institut, Langen, Germany |
| Genetic information | A 552 bp fragment of the coding region contained within exon 3 was replaced with a 1.1 kb cassette containing the TK promoter followed by the neomycin gene. |
| Phenotypic information | Resistant to prion infection. |
| Breeding history | Strain was backcrossed to N20 using C57BL/6NHsd obtained from Harlan. Thereafter, the strain was bred to homozygosity again and kept by intercrossing. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | homozygous C57BL/6N males, wild-type C57BL/6N females |
| Stage of embryos | 2-cell |
Orphanet associated rare diseases, based on orthologous gene matching
