C.129P2(B6)-Ass1tm1.1Ekoe/Cnbc

Status

Available to order

EMMA IDEM:05208
Citation informationRRID:IMSR_EM:05208 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC.129P2(B6)-Ass1tm1.1Ekoe/Cnbc
Alternative nameASS flox/flox Balb/c
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolAss1tm1.1Ekoe
Gene/Transgene symbolAss1

Information from provider

ProviderWouter Lamers
Provider affiliationMaastricht University
Genetic informationBALB/c (original mutant mouse backcrossed for more than 10 generations).
Phenotypic informationNo phenotype as flox/flox. Phenotype depends on the specific cre recombinase crossing. Homozygous knock-out mice have same phenotype as classical argininosuccinate synthetase 1 (Ass1) knock-out. Ass1 plays an essential role in the urea cycle, and in local arginine synthesis (kidney, macrophages, endothelial cells).
Breeding historyBackcrossed to BALB/c for more than 10 generations, now bred as Ass1 flox/flox BALB/c X Ass1 flox/flox BALB/c.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivinghomozygous BALB/c males, homozygous BALB/c females
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal hair follicle morphology / MGI
  • alopecia / MGI
  • sparse hair / MGI
  • delayed hair appearance / MGI
  • tremors / MGI
  • abnormal cerebellum external granule cell layer morphology / MGI
  • abnormal cerebellar granule layer morphology / MGI
  • wrinkled skin / MGI
  • epidermal hyperplasia / MGI
  • hyperkeratosis / MGI
  • decreased body length / MGI
  • decreased body size / MGI
  • circling / MGI
  • abnormal gait / MGI
  • postnatal lethality / MGI
  • premature death / MGI
  • no abnormal phenotype detected / MGI
  • decreased brain weight / MGI
  • oxidative stress / MGI
  • abnormal hair follicle development / MGI
  • increased circulating ammonia level / MGI
  • abnormal circulating amino acid level / MGI
  • hearing/vestibular/ear phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • abnormal cerebellar granule cell migration / MGI
  • abnormal Bergmann glial cell morphology / MGI
  • neonatal lethality, complete penetrance / MGI
  • increased circulating citrulline level / MGI
  • decreased circulating arginine level / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

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