MGI phenotypes (allele matching)
C.129P2(Cg)-Arg1tm1Ekoe/Cnbc
| Status | Available to order |
| EMMA ID | EM:05209 |
| Citation information | RRID:IMSR_EM:05209 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C.129P2(Cg)-Arg1tm1Ekoe/Cnbc |
| Alternative name | Arg1 flox/flox Balb/c |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Arg1tm1Ekoe |
| Gene/Transgene symbol | Arg1 |
Information from provider
| Provider | Wouter Lamers |
| Provider affiliation | Maastricht University |
| Genetic information | BALB/c (original mutant mouse backcrossed for more than 10 generations). |
| Phenotypic information | No phenotype as flox/flox. Phenotype depends on the specific cre recombinase crossing. Homozygous KO have same phenotype as classical arginase 1 (Arg1) KO. Arg1 plays an essential role in the urea cycle, and in local arginine synthesis breakdown (macrophages, small intestine). |
| Breeding history | Backcrossed to BALB/c for more than 10 generations, now bred as Arg1 flox/flox BALB/c X Arg1 flox/flox BALB/c. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous BALB/c males, homozygous BALB/c females |
| Stage of embryos | 8-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Argininemia / Orphanet_90
MGI phenotypes (gene matching)
- abnormal liver morphology / MGI
- enlarged liver / MGI
- pale liver / MGI
- abnormal hepatocyte morphology / MGI
- abnormal homeostasis / MGI
- postnatal lethality / MGI
- abnormal hepatobiliary system morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal macrophage physiology / MGI
- nervous system phenotype / MGI
- increased circulating ammonia level / MGI
- abnormal circulating amino acid level / MGI
- abnormal blood homeostasis / MGI
- increased macrophage nitric oxide production / MGI
- postnatal lethality, complete penetrance / MGI
- increased circulating histidine level / MGI
- increased circulating citrulline level / MGI
- decreased circulating ornithine level / MGI
- increased circulating arginine level / MGI
- decreased circulating proline level / MGI