B6.Cg-Tg(S100A8-PML*K160R/RARA)21Hdt/Orl
| Status | Available to order |
| EMMA ID | EM:05245 |
| Citation information | RRID:IMSR_EM:05245 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(S100A8-PML*K160R/RARA)21Hdt/Orl |
| Alternative name | PML-RARa K160-21 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(S100A8-PML*K160R/RARA)21Hdt |
| Gene/Transgene symbol | Tg(S100A8-PML*K160R/RARA)21Hdt |
Information from provider
| Provider | Hugues De The |
| Provider affiliation | UMR7212 / U944, Université Paris VII - CNRS/ INSERM |
| Additional owner | Pr Hugues de Thé |
| Genetic information | PML-RARalpha with K160 sumoylation site mutation transgenic mice. PML-RARa is the chromosomal translocation responsible for Acute Promyelocytic Leukemia |
| Phenotypic information | skin diseases |
| Breeding history | 6 generations |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Literature references
- A sumoylation site in PML/RARA is essential for leukemic transformation.;Zhu Jun, Zhou Jun, Peres Laurent, Riaucoux Florence, Honoré Nicole, Kogan Scott, de Thé Hugues, ;2005;Cancer cell;7;143-53; 15710327