IMPC phenotypes (gene matching)
B6.NOD(C)-Ndrg1str/H
| Status | Available to order |
| EMMA ID | EM:05263 |
| Citation information | RRID:IMSR_EM:05263 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.NOD(C)-Ndrg1str/H |
| Alternative name | str/C57Bl6J |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Ndrg1str |
| Gene/Transgene symbol | Ndrg1 |
Information from provider
| Provider | Rosalind King |
| Provider affiliation | CBU, UCL |
| Genetic information | Ndrg1str; deletion of exons 10-14. |
| Phenotypic information | Mice at first develop normally but around the age of 5-6 weeks develop a peripheral demyelinating neuropathy resulting in weakness of the hind limbs. This manifests as clasping hind legs when suspended by tail, marked tremor, inability to maintain normal posture. Signs progress rapidly at first, stabilise after 20 weeks. |
| Breeding history | Received on BALB/c backcrossed onto C57BL/6 background, 8 generations. Currently bred using heterozygote pairs, young homozygotes can be used, 50% change of a litter but not more than 2 litters obtained. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6J males |
| Breeding at archiving centre | Males were archived upon arrival. No breeding was performed at the archiving centre. Heterozygous and homozygous males were imported |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Charcot-Marie-Tooth disease type 4D / Orphanet_99950
MGI phenotypes (gene matching)
- tremors / MGI
- weakness / MGI
- hindlimb paralysis / MGI
- demyelination / MGI
- peripheral nervous system degeneration / MGI
- decreased body size / MGI
- cataract / MGI
- limb grasping / MGI
- increased T cell derived lymphoma incidence / MGI
- premature death / MGI
- abnormal T cell physiology / MGI
- decreased cellular sensitivity to gamma-irradiation / MGI
- increased incidence of tumors by chemical induction / MGI
- decreased nerve conduction velocity / MGI
- decreased sensitivity to induced cell death / MGI
- skeletal muscle atrophy / MGI
- paraparesis / MGI
- decreased thymocyte apoptosis / MGI
Literature references
- Ndrg1 in development and maintenance of the myelin sheath.;King Rosalind H M, Chandler David, Lopaticki Sash, Huang Dexing, Blake Julian, Muddle John R, Kilpatrick Trevor, Nourallah Michelle, Miyata Toshiyuki, Okuda Tomohiko, Carter Kim W, Hunter Michael, Angelicheva Dora, Morahan Grant, Kalaydjieva Luba, ;2011;Neurobiology of disease;42;368-80; 21303696