B6CBA-Tg(S100A8-PML/RARA*M883R*T886R)14Hdt/Orl
| Status | Available to order |
| EMMA ID | EM:05281 |
| Citation information | RRID:IMSR_EM:05281 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6CBA-Tg(S100A8-PML/RARA*M883R*T886R)14Hdt/Orl |
| Alternative name | PML/RARA M883R, T886R |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(S100A8-PML/RARA*M883R*T886R)14Hdt |
| Gene/Transgene symbol | Tg(S100A8-PML/RARA*M883R*T886R)14Hdt |
Information from provider
| Provider | Hugues De The |
| Provider affiliation | UMR7212 / U944, Université Paris VII - CNRS/ INSERM |
| Genetic information | Transgenic mice expressing PML-RARalpha with M883R, T886R RXR binding site mutations. PML-RARa is the chromosomal translocation responsible for Acute Promyelocytic Leukemia (APL). |
| Phenotypic information | Sometimes large spleen development but never APL. |
| Breeding history | 6 generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6 x CBA males, wild-type C57BL/6 x CBA females |
Literature references
- RXR is an essential component of the oncogenic PML/RARA complex in vivo.;Zhu Jun, Nasr Rihab, Pérès Laurent, Riaucoux-Lormière Florence, Honoré Nicole, Berthier Caroline, Kamashev Dmitrii, Zhou Jun, Vitoux Dominique, Lavau Catherine, de Thé Hugues, ;2007;Cancer cell;12;23-35; 17613434