IMPC phenotypes (gene matching)
- increased defecation amount / IMPC
B6.129-Aifm2tm1Marc/Ieg
| Status | Available to order |
| EMMA ID | EM:05283 |
| Citation information | RRID:IMSR_EM:05283 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Aifm2tm1Marc/Ieg |
| Alternative name | Aifm2 (apoptosis-inducing factor, mitochondrion-associated 2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Aifm2tm1Marc |
| Gene/Transgene symbol | Aifm2 |
Information from provider
| Provider | Marcus CONRAD |
| Provider affiliation | Institute of Developmental Genetics, Helmholtz Zentrum Muenchen |
| Genetic information | Exons 4, 5 and an alternative exon of the Aifm2 gene were replaced by a lacZ-neo cassette. |
| Phenotypic information | The mice are fully viable and fertile and do not show any overt abnormalities. This mouse strain was among the first lines to be screened in the GMC (approx. 2003/2004). No phenotype could be detected by the GMC. |
| Breeding history | Inbred for more than 10 generations on the C57BL/6J background. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Literature references
- Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.;Tonnus Wulf, Meyer Claudia, Steinebach Christian, Belavgeni Alexia, von Mässenhausen Anne, Gonzalez Nadia Zamora, Maremonti Francesca, Gembardt Florian, Himmerkus Nina, Latk Markus, Locke Sophie, Marschner Julian, Li Wenjun, Short Spencer, Doll Sebastian, Ingold Irina, Proneth Bettina, Daniel Christoph, Kabgani Nazanin, Kramann Rafael, Motika Stephen, Hergenrother Paul J, Bornstein Stefan R, Hugo Christian, Becker Jan Ulrich, Amann Kerstin, Anders Hans-Joachim, Kreisel Daniel, Pratt Derek, Gütschow Michael, Conrad Marcus, Linkermann Andreas, ;2021;Nature communications;12;4402; 34285231
- A non-canonical vitamin K cycle is a potent ferroptosis suppressor.;Mishima Eikan, Ito Junya, Wu Zijun, Nakamura Toshitaka, Wahida Adam, Doll Sebastian, Tonnus Wulf, Nepachalovich Palina, Eggenhofer Elke, Aldrovandi Maceler, Henkelmann Bernhard, Yamada Ken-Ichi, Wanninger Jonas, Zilka Omkar, Sato Emiko, Feederle Regina, Hass Daniela, Maida Adriano, Mourão André Santos Dias, Linkermann Andreas, Geissler Edward K, Nakagawa Kiyotaka, Abe Takaaki, Fedorova Maria, Proneth Bettina, Pratt Derek A, Conrad Marcus, ;2022;Nature;608;778-783; 35922516