MGI phenotypes (allele matching)
B6.129-Ppardtm1(PPARD)Bsls/Orl
| Status | Available to order |
| EMMA ID | EM:05315 |
| Citation information | RRID:IMSR_EM:05315 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Ppardtm1(PPARD)Bsls/Orl |
| Alternative name | hPPARd KI |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Ppardtm1(PPARD)Bsls |
| Gene/Transgene symbol | Ppard |
Information from provider
| Provider | Barbara Gross |
| Provider affiliation | Unité animale et laboratoire de haute sécurité, Institut Pasteur de Lille |
| Genetic information | The coding region (from exon 3 to exon 8) of mouse PPARd was replaced by the human cDNA of human PPARd by gene targeting in ES cells. |
| Phenotypic information | Decreased level of HDL-cholesterol in untreated mice. Fully responsive to treatment with PPAR-specific compound GW610742. |
| Breeding history | 10th generation of backcross to C57BL/6 mice. Currently bred as a homozygous colony. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous males, wild-type females |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal adipose tissue morphology / MGI
- decreased bone mineral density / MGI
- decreased circulating HDL cholesterol level / MGI
- hypoglycemia / MGI
- underdeveloped hair follicles / MGI
- muscle weakness / MGI
- decreased brain size / MGI
- dilated lateral ventricles / MGI
- abnormal myelination / MGI
- thin skin / MGI
- thick epidermis / MGI
- epidermal hyperplasia / MGI
- abnormal epidermis stratum corneum morphology / MGI
- decreased body size / MGI
- abnormal lipid level / MGI
- increased circulating triglyceride level / MGI
- abnormal placenta development / MGI
- postnatal growth retardation / MGI
- reduced fertility / MGI
- increased tumor incidence / MGI
- increased skin papilloma incidence / MGI
- prenatal lethality / MGI
- abnormal extraembryonic tissue morphology / MGI
- abnormal brain morphology / MGI
- delayed wound healing / MGI
- increased intestinal adenocarcinoma incidence / MGI
- decreased aerobic running capacity / MGI
- abnormal hair follicle development / MGI
- abnormal compact bone morphology / MGI
- decreased lean body mass / MGI
- embryonic growth retardation / MGI
- decreased thermal nociceptive threshold / MGI
- thin hypodermis / MGI
- decreased fetal size / MGI
- increased incidence of tumors by chemical induction / MGI
- decreased skeletal muscle mass / MGI
- skin inflammation / MGI
- increased osteoclast cell number / MGI
- decreased bone strength / MGI
- increased bone resorption / MGI
- increased circulating VLDL cholesterol level / MGI
- decreased circulating cholesterol level / MGI
- increased fatty acid level / MGI
- impaired glucose tolerance / MGI
- abnormal gonadal fat pad morphology / MGI
- homeostasis/metabolism phenotype / MGI
- abnormal circulating protein level / MGI
- abnormal energy expenditure / MGI
- intestine polyps / MGI
- abnormal bone ossification / MGI
- decreased subcutaneous adipose tissue amount / MGI
- abnormal fat cell morphology / MGI
- decreased abdominal fat pad weight / MGI
- decreased interscapular fat pad weight / MGI
- decreased mesenteric fat pad weight / MGI
- decreased liver triglyceride level / MGI
- increased keratinocyte apoptosis / MGI
- increased keratinocyte proliferation / MGI
- decreased keratinocyte proliferation / MGI
- abnormal stratum corneum lipid matrix formation / MGI
- increased total body fat amount / MGI
- decreased liver cholesterol level / MGI
- increased skin tumor incidence / MGI
- decreased bone volume / MGI
- abnormal compact bone volume / MGI
- prenatal lethality, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased placental labyrinth size / MGI
- impaired osteoblast differentiation / MGI
- abnormal response to exercise / MGI
- increased sebaceous gland adenoma incidence / MGI
- decreased bone stiffness / MGI
- decreased energy dissipated prior to femur fracture / MGI
- decreased bone mineral density of femur / MGI
- increased bone marrow adipose tissue amount / MGI
- abnormal keratinocyte adhesion / MGI
- abnormal hair follicle peg morphology / MGI
Literature references
- Generation and characterization of a humanized PPARδ mouse model.;Gross B, Hennuyer N, Bouchaert E, Rommens C, Grillot D, Mezdour H, Staels B, ;2011;British journal of pharmacology;164;192-208; 21426320