MGI phenotypes (allele matching)
B6.129S2(SJL)-Trdntm1.2Isma/Orl
| Status | Available to order |
| EMMA ID | EM:05317 |
| Citation information | RRID:IMSR_EM:05317 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2(SJL)-Trdntm1.2Isma/Orl |
| Alternative name | Triadin-KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Trdntm1.2Isma |
| Gene/Transgene symbol | Trdn |
Information from provider
| Provider | Isabelle Marty |
| Provider affiliation | Equipe 4, Grenoble Institut des Neurosciences - INSERM U836 |
| Genetic information | Knock out of the Trdn (Triadin) gene. |
| Phenotypic information | Muscle weakness, cardiac hypertrophy, stress- and effort- induced tachycardia. |
| Breeding history | Backcrossed for 5 generations. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6N males, wild-type C57BL/6N females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Romano-Ward syndrome / Orphanet_101016
- Catecholaminergic polymorphic ventricular tachycardia / Orphanet_3286
MGI phenotypes (gene matching)
- abnormal muscle physiology / MGI
- no phenotypic analysis / MGI
- abnormal sarcoplasmic reticulum morphology / MGI
- abnormal muscle electrophysiology / MGI
- growth/size/body region phenotype / MGI
- abnormal skeletal muscle fiber triad morphology / MGI
- skeletal muscle hypertrophy / MGI
- decreased grip strength / MGI
Literature references
- Triadin deletion induces impaired skeletal muscle function.;Oddoux Sarah, Brocard Julie, Schweitzer Annie, Szentesi Peter, Giannesini Benoit, Brocard Jacques, Fauré Julien, Pernet-Gallay Karine, Bendahan David, Lunardi Joël, Csernoch Laszlo, Marty Isabelle, ;2009;The Journal of biological chemistry;284;34918-29; 19843516