MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
STOCK Mlanatm1.1Bee/Cnbc
| Status | Available to order |
| EMMA ID | EM:05333 |
| Citation information | RRID:IMSR_EM:05333 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Mlanatm1.1Bee/Cnbc |
| Alternative name | Mlana |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Mlanatm1.1Bee |
| Gene/Transgene symbol | Mlana |
Information from provider
| Provider | Friedrich Beermann |
| Provider affiliation | EPFL SV ISREC |
| Genetic information | A conditional allele of the Mart-1/Mlana gene was constructed by inserting loxP sites 5' to exon 2 (containing the ATG) and 3' to exon 3. A neomycin resistance cassette has been removed by flpase (leaving a frt site). Cre/loxP recombination is working and is able to generate a Mlana ko allele. |
| Phenotypic information | This conditional allele has no phenotype. Removal of loxP-flanked exons of Mlana in homozygous situation will result in a coat color dilution and absence of Mlana/Mart-1 protein. |
| Breeding history | The mouse was backcrossed at least twice to C57BL/6N. It is currently kept as homozygous x homozygous matings. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6N males |
Disease and phenotype information
Literature references
- Coat color dilution in mice because of inactivation of the melanoma antigen MART-1.;Aydin Iraz T, Hummler Edith, Smit Nico P M, Beermann Friedrich, ;2012;Pigment cell & melanoma research;25;37-46; 21943097