IMPC phenotypes (gene matching)
B6.129X1(CD1)-Kat2btm1Nkt/Orl
| Status | Available to order |
| EMMA ID | EM:05396 |
| Citation information | RRID:IMSR_EM:05396 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129X1(CD1)-Kat2btm1Nkt/Orl |
| Alternative name | C57/BL6 PCAF -/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Kat2btm1Nkt |
| Gene/Transgene symbol | Kat2b |
Information from provider
| Provider | Céline Gongora |
| Provider affiliation | IRCM INSERM U896 |
| Genetic information | The exon encoding the N-terminus of Kat2b (PCAF) was replaced by a neomycin resistance gene cassette in the targeting vector. Targeted ES clones (129/SvJ) were injected into C57BL/6 mouse blastocysts and implanted into foster mothers, resulting in several chimeric offspring. Chimeras were bred with CD1 or C57BL/6 females to produce heterozygous mice. |
| Phenotypic information | Homozygous Kat2b (Pcaf) -/- mice in C57BL/6 background display alterations of the working memory. |
| Breeding history | Chimeras were bred with CD1 or C57BL/6 females to produce heterozygous mice. CD1 Kat2b (PCAF) -/- mice were produced during 4 years and backcrossed onto C57BL/6 background for at least 15 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males, wild-type C57BL/6J females |
Disease and phenotype information
MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
Literature references
- Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis.;Yamauchi T, Yamauchi J, Kuwata T, Tamura T, Yamashita T, Bae N, Westphal H, Ozato K, Nakatani Y, ;2000;Proceedings of the National Academy of Sciences of the United States of America;97;11303-6; 11027331