IMPC phenotypes (gene matching)
CD1.129X1-Kat2btm1Nkt/Orl
| Status | Available to order |
| EMMA ID | EM:05397 |
| Citation information | RRID:IMSR_EM:05397 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | CD1.129X1-Kat2btm1Nkt/Orl |
| Alternative name | PCAF -/- CD1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Kat2btm1Nkt |
| Gene/Transgene symbol | Kat2b |
Information from provider
| Provider | Céline Gongora |
| Provider affiliation | IRCM INSERM U896 |
| Genetic information | The exon encoding the N terminus of Kat2b (PCAF) was replaced by a neomycin resistance gene cassette in the targeting vector. Targeted ES clones (129/SvJ) were injected into C57BL/6 mouse blastocysts and implanted into foster mothers, resulting in several chimeric offspring. Chimeras were bred with CD1 or C57BL/6 females to produce heterozygous mice. |
| Phenotypic information | Homozygous Kat2b (PCAF) -/- mice in CD1 background display short-term memory deficits that evolved with age towards long-term memory alteration and an exaggerated response to stress. The mice also develop resistance to amyloid toxicity. |
| Breeding history | Chimeras were bred with CD1 or C57BL/6 females to produce heterozygous mice. CD1 Kat2b (PCAF) -/- mice are produced since 1999 (at least 30 generations). |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous CD-1 males, wild-type CD-1 females |
Disease and phenotype information
MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
Literature references
- Mice knock out for the histone acetyltransferase p300/CREB binding protein-associated factor develop a resistance to amyloid toxicity.;Duclot F, Meffre J, Jacquet C, Gongora C, Maurice T, ;2010;Neuroscience;167;850-63; 20219649
- Altered memory capacities and response to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice.;Maurice Tangui, Duclot Florian, Meunier Johann, Naert Gaëlle, Givalois Laurent, Meffre Julie, Célérier Aurélie, Jacquet Chantal, Copois Virginie, Mechti Nadir, Ozato Keiko, Gongora Céline, ;2008;Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology;33;1584-602; 17805310
- Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis.;Yamauchi T, Yamauchi J, Kuwata T, Tamura T, Yamashita T, Bae N, Westphal H, Ozato K, Nakatani Y, ;2000;Proceedings of the National Academy of Sciences of the United States of America;97;11303-6; 11027331