STOCK 2700049A03Riktm1.1Arte/H

Status

Available to order

EMMA IDEM:05448
Citation informationRRID:IMSR_EM:05448 

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International strain nameSTOCK 2700049A03Riktm1.1Arte/H
Alternative nametalpid3 floxed mutant
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbol2700049A03Riktm1.1Arte
Gene/Transgene symbol2700049A03Rik

Information from provider

Provider TaconicArtemis Germany
Provider affiliationTaconicArtemis Germany
Additional ownerCheryll Tickle, Department of Biology and Biochemistry, University of Bath, Bath, UK
Genetic informationLoxP sites were inserted flanking exons 11 and 12 of the talpid3 gene.
Phenotypic informationCrossing talpid3 (2700049A03Rik) floxed mutant mice with cre recombinase-expressing mice leads to functional inactivation of the talpid3 gene and hence loss of cilia.
Breeding historyHomozygous mice with floxed allele bred for over a year.
References
  • Generation of mice with functional inactivation of talpid3, a gene first identified in chicken.;Bangs Fiona, Antonio Nicole, Thongnuek Peerapat, Welten Monique, Davey Megan G, Briscoe James, Tickle Cheryll, ;2011;Development (Cambridge, England);138;3261-72; 21750036
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivinghomozygous C57BL/6 males
Breeding at archiving centreMales were archived upon arrival. No breeding was performed at the archiving centre.

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal cell morphology / MGI
  • abnormal left-right axis patterning / MGI
  • embryonic growth arrest / MGI
  • pericardial edema / MGI
  • hemorrhage / MGI
  • abnormal neural tube morphology / MGI
  • narrow head / MGI
  • absent embryonic cilia / MGI
  • abnormal direction of heart looping / MGI
  • abnormal lateral nasal prominence morphology / MGI
  • abnormal medial nasal prominence morphology / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

Literature references

  • Generation of mice with functional inactivation of talpid3, a gene first identified in chicken.;Bangs Fiona, Antonio Nicole, Thongnuek Peerapat, Welten Monique, Davey Megan G, Briscoe James, Tickle Cheryll, ;2011;Development (Cambridge, England);138;3261-72; 21750036

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

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