C57BL/6N-Tlr7tm1.1Arte/Ieg

Status

Available to order

EMMA IDEM:05500
Citation informationRRID:IMSR_EM:05500 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Tlr7tm1.1Arte/Ieg
Alternative nameTlr7 KO cond
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolTlr7tm1.1Arte
Gene/Transgene symbolTlr7

Information from provider

Provider Helmholtz Zentrum Muenchen
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen German Research Center for Environmental Health (GmbH)
Genetic informationExon 3 has been flanked by loxP sites, as its genetic ablation should result in loss of function by deletion of most of the open reading frame. The conditional targeted mutation has been obtained by in vivo, flp recombinase-mediated removal of the neomycin and puromycin selection markers.
Phenotypic informationTO BE PROVIDED
Breeding historyTargeting performed in C57BL/6N ES cells and confirmed by Southern blotting. Crossed to C57BL/6N-Tg(CAG-flpe)2Arte mice to obtain mutant founders with excised neo and puro cassettes. Maintained on C57BL/6N background.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivinghomozygous C57BL/6NTac males, wild-type C57BL/6N females
Stage of embryos2-cell

Disease and phenotype information

MGI phenotypes (gene matching)
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal macrophage physiology / MGI
  • decreased anti-insulin autoantibody level / MGI
  • hematopoietic system phenotype / MGI
  • decreased follicular B cell number / MGI
  • increased marginal zone B cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased circulating interferon-alpha level / MGI
  • decreased interleukin-12b secretion / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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