IMPC phenotypes (gene matching)
STOCK Stmn2tm1.1Ics/Orl
| Status | Available to order |
| EMMA ID | EM:05572 |
| Citation information | RRID:IMSR_EM:05572 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Stmn2tm1.1Ics/Orl |
| Alternative name | STMN2-KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Stmn2tm1.1Ics |
| Gene/Transgene symbol | Stmn2 |
Information from provider
| Provider | Andre SOBEL |
| Provider affiliation | UMRS 839 - Institut du Fer à Moulin, Inserm/UPMC |
| Additional owner | Institut Clinique de la Souris (ICS), Illkirch/Strasbourg, France |
| Genetic information | A cKO mouse was first constructed with loxP sites before and after exon 3 of the Stmn2 gene and crossed with a cre recombinase-expressing mouse leading to the deletion of exon 3. |
| Phenotypic information | No major metabolic or behavioral phenotypic modification of heterozygous mice was observed in a standard phenotyping protocol; no significant anatomical anomaly was observed in homozygous mice at embryonic day 18.5, but they die shortly after birth (Institut de la Clinique de la Souris). |
| Breeding history | Current genotype: C57BL/6J 0.0968%; C57BL/6N 6.1532%; 129/SvPas 0.7812%; C57BL/6NTac 92.9688% F0 |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6N males, wild-type C57BL/6N females |
Disease and phenotype information
Literature references
- Stathmin: a relay phosphoprotein for multiple signal transduction?;Sobel A, ;1991;Trends in biochemical sciences;16;301-5; 1957351
- Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin.;Curmi P A, Gavet O, Charbaut E, Ozon S, Lachkar-Colmerauer S, Manceau V, Siavoshian S, Maucuer A, Sobel A, ;1999;Cell structure and function;24;345-57; 15216892
- Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain.;Ozon S, El Mestikawy S, Sobel A, ;1999;Journal of neuroscience research;56;553-64; 10369222
- Stathmin family proteins display specific molecular and tubulin binding properties.;Charbaut E, Curmi P A, Ozon S, Lachkar S, Redeker V, Sobel A, ;2001;The Journal of biological chemistry;276;16146-54; 11278715
- The 4 A X-ray structure of a tubulin:stathmin-like domain complex.;Gigant B, Curmi P A, Martin-Barbey C, Charbaut E, Lachkar S, Lebeau L, Siavoshian S, Sobel A, Knossow M, ;2000;Cell;102;809-16; 11030624
- Regulation and subcellular localization of the microtubule-destabilizing stathmin family phosphoproteins in cortical neurons.;Gavet Olivier, El Messari Saïd, Ozon Sylvie, Sobel André, ;2002;Journal of neuroscience research;68;535-50; 12111843
- Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP.;Bièche Ivan, Maucuer Alexandre, Laurendeau Ingrid, Lachkar Sylvie, Spano Anthony J, Frankfurter Anthony, Lévy Pascale, Manceau Valérie, Sobel André, Vidaud Michel, Curmi Patrick A, ;2003;Genomics;81;400-10; 12676564
- Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.;Ravelli Raimond B G, Gigant Benoît, Curmi Patrick A, Jourdain Isabelle, Lachkar Sylvie, Sobel André, Knossow Marcel, ;2004;Nature;428;198-202; 15014504
- The "SCG10-LIke Protein" SCLIP is a novel regulator of axonal branching in hippocampal neurons, unlike SCG10.;Poulain Fabienne E, Sobel André, ;2007;Molecular and cellular neurosciences;34;137-46; 17145186
- SCLIP is crucial for the formation and development of the Purkinje cell dendritic arbor.;Poulain Fabienne E, Chauvin Stéphanie, Wehrlé Rosine, Desclaux Mathieu, Mallet Jacques, Vodjdani Guilan, Dusart Isabelle, Sobel André, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;7387-98; 18632943
- Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation.;Schubart U K, Yu J, Amat J A, Wang Z, Hoffmann M K, Edelmann W, ;1996;The Journal of biological chemistry;271;14062-6; 8662897
- stathmin, a gene enriched in the amygdala, controls both learned and innate fear.;Shumyatsky Gleb P, Malleret Gaël, Shin Ryong-Moon, Takizawa Shuichi, Tully Keith, Tsvetkov Evgeny, Zakharenko Stanislav S, Joseph Jamie, Vronskaya Svetlana, Yin DeQi, Schubart Ulrich K, Kandel Eric R, Bolshakov Vadim Y, ;2005;Cell;123;697-709; 16286011