MGI phenotypes (allele matching)
B6;129-Cbx3tm1Pbs/Cnbc
| Status | Available to order |
| EMMA ID | EM:05619 |
| Citation information | RRID:IMSR_EM:05619 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Cbx3tm1Pbs/Cnbc |
| Alternative name | Cbx3 hypo |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Cbx3tm1Pbs |
| Gene/Transgene symbol | Cbx3 |
Information from provider
| Provider | Prim Singh |
| Provider affiliation | Institut für Zell- und Neurobiologie |
| Genetic information | Targeting of the mouse Cbx3 gene with a conditional targeting vector produced a hypomorphic allele (Cbx3 hypo allele). |
| Phenotypic information | Homozygotes (Cbx3 hypo/hypo) are infertile. Heterozygous males breed fine. |
| Breeding history | The chimeras were crossed to C57BL/6 to determine germ-line transmission. Thereafter the animals were crossed interse and are on B6;129 background. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6;129 males |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- HP1gamma function is required for male germ cell survival and spermatogenesis.;Brown Jeremy P, Bullwinkel Jörn, Baron-Lühr Bettina, Billur Mustafa, Schneider Philipp, Winking Heinz, Singh Prim B, ;2010;Epigenetics & chromatin;3;9; 20423503