MGI phenotypes (allele matching)
STOCK Mlanatm1.2Bee/Cnbc
| Status | Available to order |
| EMMA ID | EM:05667 |
| Citation information | RRID:IMSR_EM:05667 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Mlanatm1.2Bee/Cnbc |
| Alternative name | Mlana |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mlanatm1.2Bee |
| Gene/Transgene symbol | Mlana |
Information from provider
| Provider | Friedrich Beermann |
| Provider affiliation | EPFL SV ISREC |
| Genetic information | Mlana/Mart-1 were deleted (in vivo) by constitutive (germline) deletion of exon 2 (containing ATG) and exon 3 from loxP sites placed in the respective introns. DNA, RNA and protein of the deleted region (and of the whole protein) were not detected in homozygous Mlana-mutant mice |
| Phenotypic information | Mice with homozygous deletion of Mlana are viable, and not reduced in fertility and physiology. These mice display a pigmentation phenotype, with slightly lighter fur. Biochemical and electron microscopy suggest a modification of melanosome structure |
| Breeding history | Strain was backcrossed at least 3-4 times to C57BL/6N, and kept as heterozygous for ease of backcrossing. To produce mutant mice for shipment, we have interbred heterozygous mutant mice. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous males |
Disease and phenotype information
Literature references
- Coat color dilution in mice because of inactivation of the melanoma antigen MART-1.;Aydin Iraz T, Hummler Edith, Smit Nico P M, Beermann Friedrich, ;2012;Pigment cell & melanoma research;25;37-46; 21943097