B6.129S2-Edc3^{Gt(A008A01)Wrst}/Ieg

Status	Available to order
EMMA ID	EM:05676
Citation information	RRID:IMSR_EM:05676 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.129S2-Edc3^{Gt(A008A01)Wrst}/Ieg
Alternative name	Edc3 (enhancer of mRNA decapping 3 homolog (S. cerevisiae))
Strain type	Gene-trap
Allele/Transgene symbol	Edc3
Gene/Transgene symbol	Edc3

Information from provider

Provider	Franz Vauti
Provider affiliation	Cell- & Molecular Biology, Technical University of Braunschweig
Genetic information	Edc3 PT1betageo gene-trap.
Phenotypic information	Abnormal adipose tissue distribution.
Breeding history	Backcrossed (N>7) into C57BL/6.
References	A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	not known

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Autosomal recessive non-syndromic intellectual disability / Orphanet_88616

IMPC phenotypes (gene matching)

abnormal eye morphology / IMPC
enlarged lymph nodes / IMPC
abnormal skin morphology / IMPC
increased mean platelet volume / IMPC
enlarged kidney / IMPC
single kidney / IMPC
abnormal kidney morphology / IMPC
increased circulating alkaline phosphatase level / IMPC
abnormal testis morphology / IMPC
enlarged urinary bladder / IMPC

Literature references

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
Not found what you were looking for? Search here for other strains available from EMMA.

INFRAFRONTIER^® and European Mouse Mutant Archive - EMMA^® are registered trademarks at the European Union Intellectual Property Office (EUIPO).

B6.129S2-Edc3Gt(A008A01)Wrst/Ieg