B6.129S2-Fubp1^{Gt(A033A08)Wrst}/VauIeg

Status	Available to order
EMMA ID	EM:05684
Citation information	RRID:IMSR_EM:05684 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.129S2-Fubp1^{Gt(A033A08)Wrst}/VauIeg
Alternative name	Fubp1 (far upstream element (FUSE) binding protein 1)
Strain type	Gene-trap
Allele/Transgene symbol	Fubp1^{Gt(A033A08)Wrst}
Gene/Transgene symbol	Fubp1

Information from provider

Provider	Franz Vauti
Provider affiliation	Cell- & Molecular Biology, Technical University of Braunschweig
Genetic information	Fubp1 Gt PT1betageo.
Phenotypic information	Not known; mouse line not yet characterized.
Breeding history	Backcrossed into C57BL/6 (N>7).
References	A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583 Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells.;Wiles M V, Vauti F, Otte J, Füchtbauer E M, Ruiz P, Füchtbauer A, Arnold H H, Lehrach H, Metz T, von Melchner H, Wurst W, ;2000;Nature genetics;24;13-4; 10615117
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	not known
Immunocompromised	not known

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archiving	heterozygous C57BL/6J males

Disease and phenotype information

IMPC phenotypes (gene matching)

decreased thigmotaxis / IMPC
decreased locomotor activity / IMPC
preweaning lethality, complete penetrance / IMPC
abnormal behavior / IMPC
enlarged lymph nodes / IMPC
dysplasia / IMPC
abnormal retina morphology / IMPC
abnormal skin morphology / IMPC
decreased anxiety-related response / IMPC
abnormal lymph node morphology / IMPC

MGI phenotypes (gene matching)

decreased bone marrow cell number / MGI
small liver / MGI
pale liver / MGI
spleen hypoplasia / MGI
abnormal stratification in cerebral cortex / MGI
pulmonary hypoplasia / MGI
anemia / MGI
cardiac hypertrophy / MGI
abnormal placenta morphology / MGI
thymus hypoplasia / MGI
hemorrhage / MGI
abnormal definitive hematopoiesis / MGI
abnormal blood circulation / MGI
abnormal brain morphology / MGI
lymphoid hypoplasia / MGI
small lung / MGI
pallor / MGI
decreased fetal size / MGI
decreased B cell number / MGI
absent cerebellar lobules / MGI
decreased megakaryocyte cell number / MGI
abnormal cerebral hemisphere morphology / MGI
abnormal hematopoietic stem cell physiology / MGI
prenatal growth retardation / MGI
abnormal prenatal body size / MGI
abnormal pulmonary alveolar sac morphology / MGI
impaired branching involved in alveolar sac morphogenesis / MGI
neonatal lethality, complete penetrance / MGI
perinatal lethality, incomplete penetrance / MGI
prenatal lethality, incomplete penetrance / MGI
thin placenta labyrinth / MGI
abnormal placenta intervillous maternal lacunae morphology / MGI
abnormal hematopoietic precursor cell number / MGI

Literature references

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583
Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells.;Wiles M V, Vauti F, Otte J, Füchtbauer E M, Ruiz P, Füchtbauer A, Arnold H H, Lehrach H, Metz T, von Melchner H, Wurst W, ;2000;Nature genetics;24;13-4; 10615117

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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B6.129S2-Fubp1Gt(A033A08)Wrst/VauIeg