B6.129S2-Tpm3^{Gt(A062D07)Wrst}/Ieg

Status	Available to order
EMMA ID	EM:05685
Citation information	RRID:IMSR_EM:05685 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.129S2-Tpm3^{Gt(A062D07)Wrst}/Ieg
Alternative name	Tpm3 (tropomyosin 3, gamma)
Strain type	Gene-trap
Allele/Transgene symbol	Tpm3^{Gt(A062D07)Wrst}
Gene/Transgene symbol	Tpm3

Information from provider

Provider	Franz Vauti
Provider affiliation	Cell- & Molecular Biology, Technical University of Braunschweig
Genetic information	Tpm3 PT1betageo gene-trap.
Phenotypic information	Not known; mouse line not yet characterized.
Breeding history	Backcrossed into C57BL/6 (N>7).
References	A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583 Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells.;Wiles M V, Vauti F, Otte J, Füchtbauer E M, Ruiz P, Füchtbauer A, Arnold H H, Lehrach H, Metz T, von Melchner H, Wurst W, ;2000;Nature genetics;24;13-4; 10615117
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	not known
Immunocompromised	not known

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archiving	heterozygous C57BL/6J males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Congenital generalized hypercontractile muscle stiffness syndrome / Orphanet_476406
Intermediate nemaline myopathy / Orphanet_171433
Cap myopathy / Orphanet_171881
Congenital fiber-type disproportion myopathy / Orphanet_2020
Childhood-onset nemaline myopathy / Orphanet_171439

MGI phenotypes (gene matching)

abnormal muscle morphology / MGI
no phenotypic analysis / MGI
nervous system phenotype / MGI
abnormal muscle contractility / MGI
embryonic lethality before implantation, complete penetrance / MGI

Literature references

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583
Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells.;Wiles M V, Vauti F, Otte J, Füchtbauer E M, Ruiz P, Füchtbauer A, Arnold H H, Lehrach H, Metz T, von Melchner H, Wurst W, ;2000;Nature genetics;24;13-4; 10615117

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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B6.129S2-Tpm3Gt(A062D07)Wrst/Ieg