C57BL/6N-Slc17a8tm2Selm/Ics

Status

Available to order

EMMA IDEM:05733
Citation informationRRID:IMSR_EM:05733 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Slc17a8tm2Selm/Ics
Alternative nameVGluT3cKO
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolSlc17a8tm2Selm
Gene/Transgene symbolSlc17a8

Information from provider

ProviderSalah El Mestikawy
Provider affiliationU952 INSERM CNRS UMR7224, Université Paris 6, PMSNC
Genetic informationTwo loxP sites have been inserted around exon2 of the Slc17a8 (Vglut3) gene.
Phenotypic informationNot characterised.
Breeding historyThis line was created on C57BL/6N background and maintained on this same background.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France
Animals used for archivingheterozygous C57BL/6NTac males, wild-type C57BL/6NTac females
Stage of embryos8-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Autosomal dominant non-syndromic sensorineural deafness type DFNA / Orphanet_90635
IMPC phenotypes (gene matching)
  • enlarged lymph nodes / IMPC
  • abnormal auditory brainstem response / IMPC
  • abnormal colon morphology / IMPC
  • decreased prepulse inhibition / IMPC
  • decreased startle reflex / IMPC
  • decreased exploration in new environment / IMPC
  • abnormal lymph node morphology / IMPC
  • abnormal adrenal gland morphology / IMPC
  • abnormal uterus morphology / IMPC
  • abnormal eye morphology / IMPC
  • enlarged uterus / IMPC
  • cataract / IMPC
  • abnormal kidney morphology / IMPC
  • abnormal startle reflex / IMPC
MGI phenotypes (gene matching)
  • nonconvulsive seizures / MGI
  • hyperactivity / MGI
  • deafness / MGI
  • abnormal cochlear ganglion morphology / MGI
  • cochlear ganglion degeneration / MGI
  • abnormal neurotransmitter uptake / MGI
  • decreased cochlear inner hair cell number / MGI
  • absent cochlear nerve compound action potential / MGI
  • abnormal cochlear inner hair cell physiology / MGI
  • decreased synaptic glutamate release / MGI
  • abnormal inner hair cell synaptic ribbon morphology / MGI
  • abnormal cochlear IHC efferent innervation pattern / MGI
  • abnormal auditory brainstem response / MGI
  • sensorineural hearing loss / MGI
  • abnormal synaptic acetylcholine release / MGI
  • abnormal brain wave pattern / MGI
  • hearing/vestibular/ear phenotype / MGI
  • absent startle reflex / MGI
  • impaired behavioral response to xenobiotic / MGI
  • enhanced behavioral response to cocaine / MGI
  • increased or absent threshold for auditory brainstem response / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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