B6.129-Glce^tm1Jpli/Kctt

Status	Available to order
EMMA ID	EM:05825
Citation information	RRID:IMSR_EM:05825 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.129-Glce^tm1Jpli/Kctt
Alternative name	Hsepi-KO
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Glce^tm1Jpli
Gene/Transgene symbol	Glce

Information from provider

Provider	Jin-Ping Li
Provider affiliation	Medical Biochemistry and Microbiology
Genetic information	See Li et al. 2003 (JBC).
Phenotypic information	Homozygous neonatal lethal. Multiple development defects described in literature references.
Breeding history	Cross-bred to C57BL/6 for 10 generations.
References	Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.;Reijmers Rogier M, Groen Richard W J, Kuil Annemieke, Weijer Kees, Kimberley Fiona C, Medema Jan Paul, van Kuppevelt Toin H, Li Jin-Ping, Spaargaren Marcel, Pals Steven T, ;2011;Blood;117;6162-71; 21471524 Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling.;Jia Juan, Maccarana Marco, Zhang Xiao, Bespalov Maxim, Lindahl Ulf, Li Jin-Ping, ;2009;The Journal of biological chemistry;284;15942-50; 19336402 Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase.;Reijmers Rogier M, Vondenhoff Mark F R, Roozendaal Ramon, Kuil Annemieke, Li Jin-Ping, Spaargaren Marcel, Pals Steven T, Mebius Reina E, ;2010;Journal of immunology (Baltimore, Md. : 1950);184;3656-64; 20208005 Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality.;Li Jin-Ping, Gong Feng, Hagner-McWhirter Asa, Forsberg Erik, Abrink Magnus, Kisilevsky Robert, Zhang Xiao, Lindahl Ulf, ;2003;The Journal of biological chemistry;278;28363-6; 12788935
Homozygous fertile	not known
Homozygous viable	no
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Karolinska Institutet, Stockholm, Sweden

Disease and phenotype information

MGI phenotypes (allele matching)

cleft palate / MGI
abnormal sternum morphology / MGI
absent kidney / MGI
polydactyly / MGI
abnormal lung morphology / MGI
decreased body length / MGI
respiratory failure / MGI
abnormal skeleton development / MGI
abnormal bone mineralization / MGI
curly tail / MGI
abnormal thoracic cage morphology / MGI
abnormal phalanx morphology / MGI
absent tarsus bones / MGI
iris coloboma / MGI
abnormal pulmonary alveolus wall morphology / MGI
neonatal lethality, complete penetrance / MGI

MGI phenotypes (gene matching)

cleft palate / MGI
abnormal sternum morphology / MGI
absent kidney / MGI
polydactyly / MGI
abnormal lung morphology / MGI
decreased body length / MGI
respiratory failure / MGI
abnormal skeleton development / MGI
abnormal bone mineralization / MGI
curly tail / MGI
abnormal thoracic cage morphology / MGI
abnormal phalanx morphology / MGI
absent tarsus bones / MGI
iris coloboma / MGI
abnormal pulmonary alveolus wall morphology / MGI
neonatal lethality, complete penetrance / MGI

Literature references

Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.;Reijmers Rogier M, Groen Richard W J, Kuil Annemieke, Weijer Kees, Kimberley Fiona C, Medema Jan Paul, van Kuppevelt Toin H, Li Jin-Ping, Spaargaren Marcel, Pals Steven T, ;2011;Blood;117;6162-71; 21471524
Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling.;Jia Juan, Maccarana Marco, Zhang Xiao, Bespalov Maxim, Lindahl Ulf, Li Jin-Ping, ;2009;The Journal of biological chemistry;284;15942-50; 19336402
Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase.;Reijmers Rogier M, Vondenhoff Mark F R, Roozendaal Ramon, Kuil Annemieke, Li Jin-Ping, Spaargaren Marcel, Pals Steven T, Mebius Reina E, ;2010;Journal of immunology (Baltimore, Md. : 1950);184;3656-64; 20208005
Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality.;Li Jin-Ping, Gong Feng, Hagner-McWhirter Asa, Forsberg Erik, Abrink Magnus, Kisilevsky Robert, Zhang Xiao, Lindahl Ulf, ;2003;The Journal of biological chemistry;278;28363-6; 12788935

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

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B6.129-Glcetm1Jpli/Kctt