MGI phenotypes (allele matching)
B6.129S2-Syndig1ltm1Embr/Orl
| Status | Available to order |
| EMMA ID | EM:05845 |
| Citation information | RRID:IMSR_EM:05845 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2-Syndig1ltm1Embr/Orl |
| Alternative name | CapucinKO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Syndig1ltm1Embr |
| Gene/Transgene symbol | Syndig1l |
Information from provider
| Provider | Michel de Chaldée |
| Provider affiliation | CEA |
| Genetic information | The entire coding region of Capucin (also referred to as Tmem90a or Syndig1l) was replaced by a cassette containing the beta-galactosidase reporter gene. |
| Phenotypic information | Capucin knockout mice are apparently healthy and their behavior is normal at the gross level. |
| Breeding history | The mutation was introduced into AT1 ES cells (strain 129). Male chimeras were bred with C57BL/6N females and the resulting F1 mice were backcrossed to C57BL/6N for one generation and to C57BL/6J for the nine following generations. The line is currently maintained by homozygous matings. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males, wild-type C57BL/6J females |
Disease and phenotype information
Literature references
- Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo.;Galvan Laurie, Lepejová Nad'a, Gaillard Marie-Claude, Malgorn Carole, Guillermier Martine, Houitte Diane, Bonvento Gilles, Petit Fanny, Dufour Noëlle, Héry Patrick, Gérard Matthieu, Elalouf Jean-Marc, Déglon Nicole, Brouillet Emmanuel, de Chaldée Michel, ;2012;Neurobiology of aging;33;1845.e5-6; 22365050