C57BL/6-Tg(Prnp-GFP,-CBS)48Yah/Orl
| Status | Available to order |
| EMMA ID | EM:05850 |
| Citation information | RRID:IMSR_EM:05850 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Tg(Prnp-GFP,-CBS)48Yah/Orl |
| Alternative name | Tg(Gfp-hcbs) n. 48 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Prnp-GFP,-CBS)48Yah |
| Gene/Transgene symbol | Tg(Prnp-GFP,-CBS)48Yah |
Information from provider
| Provider | Yann HERAULT |
| Provider affiliation | TAAM-CDTA UPS44, CNRS-TAAM – Typing and Archiving of Animal Models |
| Genetic information | This transgene is composed by a prion promoter, a GFP cassette flanked by 2 loxP sites, a human Cbs cDNA and a SV40 polyA cassette. In physiological condition, only GFP is expressed and localized in cerebellum restricted areas. After recombination with cre-expressing mice (through user choice), GFP cassette is excised and it occurs expression of hCbs cDNA in cells coexpressing the cre recombinase transgene. |
| Phenotypic information | Without cre-mediated recombination, no abnormal phenotype is described. |
| Breeding history | Original breedings on C57BL/6J and now 93.75% C57BL/6NTac. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6NTac males, wild-type C57BL/6NTac females |
| Stage of embryos | 2-cell |