MGI phenotypes (allele matching)
B6;129-Synctm1.1Ked/H
| Status | Available to order |
| EMMA ID | EM:05906 |
| Citation information | RRID:IMSR_EM:05906 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Synctm1.1Ked/H |
| Alternative name | sync KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Synctm1.1Ked |
| Gene/Transgene symbol | Sync |
Information from provider
| Provider | Kay Davies |
| Provider affiliation | University of Oxford |
| Genetic information | Knockout of intermediate filament protein syncoilin. |
| Phenotypic information | No overt phenotype, loss of large calibre motor neurons. |
| Breeding history | Inbred, currently breeding homozygous mice. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6 males |
| Breeding at archiving centre | Males were archived upon arrival. No breeding was performed at the archiving centre. |
Disease and phenotype information
Literature references
- Analysis of skeletal muscle function in the C57BL6/SV129 syncoilin knockout mouse.;McCullagh Karl J A, Edwards Ben, Kemp Matthew W, Giles Laura C, Burgess Matthew, Davies Kay E, ;2008;Mammalian genome : official journal of the International Mammalian Genome Society;19;339-51; 18594912
- Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons.;Clarke W Thomas, Edwards Ben, McCullagh Karl J A, Kemp Matthew W, Moorwood Catherine, Sherman Diane L, Burgess Matthew, Davies Kay E, ;2010;Journal of cell science;123;2543-52; 20587592