IMPC phenotypes (gene matching)
STOCK Fntbtm1Bbd/Cnbc
| Status | Available to order |
| EMMA ID | EM:05943 |
| Citation information | RRID:IMSR_EM:05943 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Fntbtm1Bbd/Cnbc |
| Alternative name | Fntb |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Fntbtm1Bbd |
| Gene/Transgene symbol | Fntb |
Information from provider
| Provider | Mariano Barbacid |
| Provider affiliation | Molecular Oncology, Centro Nacional de Investigaciones Oncologicas |
| Genetic information | Exon 3 of the gene is flanked by loxP sites. Exon 3 encodes the catalytic subunit of the protein. |
| Phenotypic information | Before Cre mediated recombination there is no phenotype associated to this allele. The knockout allele is embryonic lethal in homozygosis. Embryos die at around E6.5. |
| Breeding history | Chimeras were crossed with CD1 females for germ line transmission analysis. Heterozygous offspring was crossed with Tg(CMV-cre)1Nagy for neomycin resistance gene excision. Offspring was intercrossed to obtain homozygous animals for the Fntb_lox allele and maintained in homozygosis. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous mixed males |
Disease and phenotype information
Literature references
- Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.;Mijimolle Nieves, Velasco Juan, Dubus Pierre, Guerra Carmen, Weinbaum Carolyn A, Casey Patrick J, Campuzano Victoria, Barbacid Mariano, ;2005;Cancer cell;7;313-24; 15837621