CD1.A-Gdf5bp-J/Orl

Status

Available to order

EMMA IDEM:05990
Citation informationRRID:IMSR_EM:05990 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameCD1.A-Gdf5bp-J/Orl
Alternative nameGdf5bp-J
Strain typeSpontaneous
Allele/Transgene symbolGdf5bp-J
Gene/Transgene symbolGdf5

Information from provider

ProviderPrzemko Tylzanowski
Provider affiliationDevelopment Growth and Regeneration, University of Leuven
Genetic informationThe mutation is caused by the insertion of a guanine residue into a stretch of three guanine residues in the gene sequence (position 1444-1448), producing a stop codon 41 amino acids later.
Phenotypic informationThe long bones of the limbs of mutant mice are slightly shorter than controls, and the fibula is shortened proximally. The bones of the axial skeleton are unaffected.
Breeding history14 backcrosses to CD1.
References
  • GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes.;Daans Melina, Luyten Frank P, Lories Rik J U, ;2011;Annals of the rheumatic diseases;70;208-13; 20805298
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archivingheterozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) males, wild-type CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) females
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal autopod morphology / IMPC
  • abnormal gait / IMPC
  • decreased exploration in new environment / IMPC
  • abnormal digit morphology / IMPC
  • decreased grip strength / IMPC
  • abnormal bone structure / IMPC
  • increased bone mineral density / IMPC
  • abnormal forelimb morphology / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased leukocyte cell number / IMPC
  • abnormal hindlimb morphology / IMPC
  • decreased locomotor activity / IMPC
  • decreased vertical activity / IMPC
  • limb grasping / IMPC
MGI phenotypes (allele matching)
  • delayed bone ossification / MGI
  • abnormal phalanx morphology / MGI
  • abnormal limb bone morphology / MGI
  • brachyphalangia / MGI
  • abnormal joint morphology / MGI
  • short metacarpal bones / MGI
  • short metatarsal bones / MGI
  • abnormal limb development / MGI
  • fused phalanges / MGI
MGI phenotypes (gene matching)
  • delayed bone ossification / MGI
  • abnormal long bone epiphysis morphology / MGI
  • abnormal cartilage morphology / MGI
  • abnormal cartilage development / MGI
  • decreased chondrocyte number / MGI
  • short limbs / MGI
  • abnormal carpal bone morphology / MGI
  • abnormal tibia morphology / MGI
  • abnormal femur morphology / MGI
  • abnormal autopod morphology / MGI
  • decreased body weight / MGI
  • reduced male fertility / MGI
  • decreased litter size / MGI
  • abnormal limb morphology / MGI
  • abnormal digit morphology / MGI
  • abnormal limb bone morphology / MGI
  • abnormal fibula morphology / MGI
  • disproportionate dwarf / MGI
  • brachyphalangia / MGI
  • brachydactyly / MGI
  • short tibia / MGI
  • short fibula / MGI
  • brachypodia / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • abnormal metatarsal bone morphology / MGI
  • abnormal metacarpal bone morphology / MGI
  • short femur / MGI
  • fused joints / MGI
  • delayed endochondral bone ossification / MGI
  • abnormal long bone morphology / MGI
  • short humerus / MGI
  • short radius / MGI
  • short ulna / MGI
  • short metacarpal bones / MGI
  • short metatarsal bones / MGI
  • decreased length of long bones / MGI
  • abnormal tarsal bone morphology / MGI
  • abnormal phalanx morphology / MGI
  • abnormal patella morphology / MGI
  • abnormal limb development / MGI
  • abnormal digit development / MGI
  • abnormal articular cartilage morphology / MGI
  • abnormal endochondral bone ossification / MGI
  • fused phalanges / MGI
  • micromelia / MGI
  • fused carpal bones / MGI
  • decreased birth weight / MGI
  • abnormal limb long bone morphology / MGI
  • joint dislocation / MGI

Literature references

  • GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes.;Daans Melina, Luyten Frank P, Lories Rik J U, ;2011;Annals of the rheumatic diseases;70;208-13; 20805298

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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