STOCK Fli1tm1.1Morl/Orl

Status

Available to order

EMMA IDEM:05992
Citation informationRRID:IMSR_EM:05992 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Fli1tm1.1Morl/Orl
Alternative nameFli1-KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolFli1tm1.1Morl
Gene/Transgene symbolFli1

Information from provider

ProviderFrancois Morle
Provider affiliationCGPhyMC , CNRS UMR5534
Genetic informationThis strain carries a single LoxP in place of the whole coding of Fli1 gene exon 9. This strain has been generated by crossing mice harboring Fli1-fl conditional allele with Sycp1Cre mice expressing Cre recombinase during male meiosis.
Phenotypic informationHeterozygotes Fli1/Fli1KO have no obvious phenotype. Although not directly tested homozygotes Fli1KO/Fli1KO are expected to die around E12 from hemorrhage and abnormal megakaryopoiesis due to loss of Fli1.
Breeding historyLoxP insertions at Fli1 locus were generated in 129P2 ES cells. Cells were injected in C57BL/6J blastocysts and backcrossed on C57BL/6J.
References
  • Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation.;Starck Joëlle, Weiss-Gayet Michèle, Gonnet Colette, Guyot Boris, Vicat Jean-Michel, Morlé François, ;2010;Blood;116;4795-805; 20733157
Homozygous fertilenot known
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archivingheterozygous C57BL/6J males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • abnormal vascular development / MGI
  • small liver / MGI
  • pale liver / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • decreased thymocyte number / MGI
  • anemia / MGI
  • impaired hematopoiesis / MGI
  • decreased embryo size / MGI
  • pale yolk sac / MGI
  • abnormal humoral immune response / MGI
  • intracranial hemorrhage / MGI
  • intraventricular hemorrhage / MGI
  • increased leukemia incidence / MGI
  • abnormal B cell differentiation / MGI
  • abnormal megakaryocyte progenitor cell morphology / MGI
  • abnormal proerythroblast morphology / MGI
  • abnormal megakaryocyte morphology / MGI
  • abnormal class switch recombination / MGI
  • decreased B cell number / MGI
  • decreased B cell proliferation / MGI
  • spinal hemorrhage / MGI
  • decreased follicular B cell number / MGI
  • increased marginal zone B cell number / MGI
  • increased transitional stage B cell number / MGI
  • decreased megakaryocyte cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG3 level / MGI
  • abnormal splenic cell ratio / MGI
  • abnormal brain meninges morphology / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

Literature references

  • Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation.;Starck Joëlle, Weiss-Gayet Michèle, Gonnet Colette, Guyot Boris, Vicat Jean-Michel, Morlé François, ;2010;Blood;116;4795-805; 20733157

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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