MGI phenotypes (allele matching)
- abnormal Langerhans cell morphology / MGI
B6N.129S2(C)-Cd207tm1Mal/Cnbc
| Status | Available to order |
| EMMA ID | EM:06003 |
| Citation information | RRID:IMSR_EM:06003 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N.129S2(C)-Cd207tm1Mal/Cnbc |
| Alternative name | Langerin (CD207) Knockout |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd207tm1Mal |
| Gene/Transgene symbol | Cd207 |
Information from provider
| Provider | Adrien Kissenpfennig |
| Provider affiliation | Centre D |
| Additional owner | Dr. A. Kissenpfennig (see above) |
| Genetic information | A general knock-out of the Langerin/Cd207 gene. Targeting construct is derived from 129/Ola genomic DNA. The deletion of the Cd207 locus spans from exon1 (inclusive of ATG start site) to exon3, as described in the original publication, to ensure complete inactivation of the Cd207 gene. |
| Phenotypic information | Mice are macroscopically normal. They possess a normal network of epidermal Langerhans cells. These Langerhans cells, however, do not contain the typical Birbeck granules. Langerhans cell function appears to be normal. |
| Breeding history | Following GLT mutant mice were backcrossed onto C57BL/6NCrl mouse background by Charles River utilising their speed backcross service. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6NCrl males, homozygous C57BL/6NCrl females |
| Stage of embryos | 4/8-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal Peyer's patch morphology / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- increased susceptibility to viral infection / MGI
- abnormal type IV hypersensitivity reaction / MGI
- immune system phenotype / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- abnormal Langerhans cell morphology / MGI
- absent Langerhans cell / MGI
- decreased Langerhans cell number / MGI
- decreased dendritic cell number / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG3 level / MGI
Literature references
- Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function.;Kissenpfennig Adrien, Aït-Yahia Smina, Clair-Moninot Valérie, Stössel Hella, Badell Edgar, Bordat Yann, Pooley Joanne L, Lang Thierry, Prina Eric, Coste Isabelle, Gresser Olivia, Renno Toufic, Winter Nathalie, Milon Geneviève, Shortman Ken, Romani Nikolaus, Lebecque Serge, Malissen Bernard, Saeland Sem, Douillard Patrice, ;2005;Molecular and cellular biology;25;88-99; 15601833