| Status | Available to order |
| EMMA ID | EM:06054 |
| Citation information | RRID:IMSR_EM:06054 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tyrc Tg(Tyr)YRT3Lmon/Cnbc |
| Alternative name | Stock HsdWin:NMRI;B6CBA-Tg(Tyr)YRT3/Lmon |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Tyr)YRT3Lmon, Tyrc |
| Gene/Transgene symbol | Tg(Tyr)YRT3Lmon, Tyr |
| Provider | Lluis Montoliu |
| Provider affiliation | Departamento de Biologia Molecular y Celular, CNB-CSIC, Centro Nacional de Biotecnologia |
| Genetic information | YAC YRT3 (Montoliu et al. 1996, EMBO J) carrying the Tyr expression domain, up to the locus control region (LCR), was re-injected (the original line was lost and could not be recovered from frozen material at DKFZ) into B6CBAF2 embryos and positive transgenic animals were backcrossed to stock albino outbred HsdWin:NMRI mice (less than 5 generations so far). |
| Phenotypic information | Pigmented mice undistinguishable from wild-type agouti mice, as compared to non-transgenic albino NMRI mice. |
| Breeding history | YAC YRT3 transgenic line originally detected in B6CBAF2 background and backcrossed to NMRI (currently less than 5 generations) where it is maintained now. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | wild-type NMRI males, homozygous NMRI females |
| Stage of embryos | 2-cell |
Orphanet associated rare diseases, based on orthologous gene matching
