IMPC phenotypes (gene matching)
B6.129-Ccr8tm1Gma/Cnbc
| Status | Available to order |
| EMMA ID | EM:06069 |
| Citation information | RRID:IMSR_EM:06069 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Ccr8tm1Gma/Cnbc |
| Alternative name | B6.129-Ccr8 tm1/Gma |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ccr8tm1Gma |
| Gene/Transgene symbol | Ccr8 |
Information from provider
| Provider | Rosa Varona |
| Provider affiliation | Centro Nacional de Biotecnologia (CNB-CSIC) |
| Genetic information | A neomycin resistance cassette replaced 508 bp preceding the ATG start site and the first 658 bp of the coding sequence. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of total thymus RNA. Mutant mice backcrossed to C57BL/6J more than 9 generations. |
| Phenotypic information | Normal phenotype |
| Breeding history | The original mutant strain was backcrossed to C57BL/6J genetic background more than 9 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous males, wild-type C57BL/6JOlaHsd females |
| Stage of embryos | 8-cell |
Disease and phenotype information
Literature references
- Absence of CCR8 does not impair the response to ovalbumin-induced allergic airway disease.;Goya Iñigo, Villares Ricardo, Zaballos Angel, Gutiérrez Julio, Kremer Leonor, Gonzalo José-Angel, Varona Rosa, Carramolino Laura, Serrano Alfredo, Pallarés Pilar, Criado Luis Miguel, Kolbeck Roland, Torres Miguel, Coyle Anthony J, Gutiérrez-Ramos José-Carlos, Martínez-A Carlos, Márquez Gabriel, ;2003;Journal of immunology (Baltimore, Md. : 1950);170;2138-46; 12574386