FVB.Cg-Tg(Kap)L49Msgr/Cnbc
| Status | Available to order |
| EMMA ID | EM:06074 |
| Citation information | RRID:IMSR_EM:06074 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB.Cg-Tg(Kap)L49Msgr/Cnbc |
| Alternative name | KAP L49 (FVB background) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Kap)L49Msgr |
| Gene/Transgene symbol | Tg(Kap)L49Msgr |
Information from provider
| Provider | Anna Meseguer |
| Provider affiliation | Vall d´Hebron Institut de Recerca (VHIR) |
| Genetic information | Mice are heterozygous for KAP Tg and we use heterozygous animals for experiments. Two different founders have been used and observed same phenotype. |
| Phenotypic information | KAP Tg mice show hypertension and increased oxidative stress. |
| Breeding history | The founder mice were backcrossed with C57BL/6 mice and with FVB. We want to save the FVB background. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous FVB/N males, wild-type FVB/N females |
| Stage of embryos | 2-cell |
Literature references
- Kidney androgen-regulated protein transgenic mice show hypertension and renal alterations mediated by oxidative stress.;Tornavaca O, Pascual G, Barreiro M L, Grande M T, Carretero A, Riera M, Garcia-Arumi E, Bardaji B, González-Núñez M, Montero M A, López-Novoa J M, Meseguer A, ;2009;Circulation;119;1908-17; 19332469
- Increased oxidative stress, the renin-angiotensin system, and sympathetic overactivation induce hypertension in kidney androgen-regulated protein transgenic mice.;Grande María T, Pascual Gloria, Riolobos Adela S, Clemente-Lorenzo Milagros, Bardaji Beatriz, Barreiro Luz, Tornavaca Olga, Meseguer Anna, López-Novoa Jose M, ;2011;Free radical biology & medicine;51;1831-41; 21906672