| Status | Available to order |
| EMMA ID | EM:06087 |
| Citation information | RRID:IMSR_EM:06087 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Myctm1.1(MYC)Gwbk/Ieg |
| Alternative name | C57BL/6-J / hc-Myc |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Myctm1.1(MYC)Gwbk |
| Gene/Transgene symbol | Myc |
| Provider | Georg W. Bornkamm |
| Provider affiliation | Institute of Experimental Genetics, GSF National Research Centre of Environment and Health |
| Genetic information | Humanized c-Myc mouse: targeted knock-in of the human c-MYC gene into the murine c-Myc locus. Human sequences starting at the CTG initiation codon of the first exon. A piece of mouse chromosome 15 (position 61.985.920 to 61.989.995) is replaced by a piece of human chromosome 8 (position 128.748.840 to 128.753.273). |
| Phenotypic information | No obvious phenotype observed. |
| Breeding history | Chimeric mice were backcrossed onto C57BL/6J, followed by mating to C57BL/6J cre deleter mice to remove the neomycin resistance gene. Then backcrossed to C57BL/6J to get rid of the cre deleter construct and brother-sister mating to generate a mouse homozygous for human c-MYC. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
