B6NTac(129S1)-Dp(7Sult1a1-Spn)7Yah/Orl

Status	Available to order
EMMA ID	EM:06134
Citation information	RRID:IMSR_EM:06134 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6NTac(129S1)-Dp(7Sult1a1-Spn)7Yah/Orl
Alternative name	16p11.2 dup
Strain type	Targeted Mutant Strains : Other targeted
Allele/Transgene symbol	Dp(7Sult1a1-Spn)7Yah
Gene/Transgene symbol	Dp(7Sult1a1-Spn)7Yah

Information from provider

Provider	Thomas ARBOGAST
Provider affiliation	IGBMC
Genetic information	Duplication of 300 kb (25 genes from Spn to Sult1a1).
Phenotypic information	Unknown.
Breeding history	Backcrossed 6-7 generations.
References	Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development.;Qiu Yuqi, Arbogast Thomas, Lorenzo Sandra Martin, Li Hongying, Tang Shih C, Richardson Ellen, Hong Oanh, Cho Shawn, Shanta Omar, Pang Timothy, Corsello Christina, Deutsch Curtis K, Chevalier Claire, Davis Erica E, Iakoucheva Lilia M, Herault Yann, Katsanis Nicholas, Messer Karen, Sebat Jonathan, ;2019;Cell reports;28;3320-3328.e4; 31553903 Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes.;Arbogast Thomas, Ouagazzal Abdel-Mouttalib, Chevalier Claire, Kopanitsa Maksym, Afinowi Nurudeen, Migliavacca Eugenia, Cowling Belinda S, Birling Marie-Christine, Champy Marie-France, Reymond Alexandre, Herault Yann, ;2016;PLoS genetics;12;e1005709; 26872257
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	yes
Immunocompromised	no

Information from EMMA

Archiving centre	CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archiving	heterozygous C57BL/6NTac males

Disease and phenotype information

MGI phenotypes (gene matching)

decreased tumor incidence / MGI
abnormal T cell physiology / MGI
decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
increased T cell proliferation / MGI
immune system phenotype / MGI
hematopoietic system phenotype / MGI

Literature references

Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development.;Qiu Yuqi, Arbogast Thomas, Lorenzo Sandra Martin, Li Hongying, Tang Shih C, Richardson Ellen, Hong Oanh, Cho Shawn, Shanta Omar, Pang Timothy, Corsello Christina, Deutsch Curtis K, Chevalier Claire, Davis Erica E, Iakoucheva Lilia M, Herault Yann, Katsanis Nicholas, Messer Karen, Sebat Jonathan, ;2019;Cell reports;28;3320-3328.e4; 31553903
Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes.;Arbogast Thomas, Ouagazzal Abdel-Mouttalib, Chevalier Claire, Kopanitsa Maksym, Afinowi Nurudeen, Migliavacca Eugenia, Cowling Belinda S, Birling Marie-Christine, Champy Marie-France, Reymond Alexandre, Herault Yann, ;2016;PLoS genetics;12;e1005709; 26872257

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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