C3HeB/FeJ-Gna11^Mhdadsk7/Ieg

Status	Available to order
EMMA ID	EM:00062
Citation information	RRID:IMSR_EM:00062 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C3HeB/FeJ-Gna11^Mhdadsk7/Ieg
Alternative name	DSK7
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Gna11^Mhdadsk7
Gene/Transgene symbol	Gna11

Information from provider

Provider	Martin Hrabe de Angelis
Provider affiliation	Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Phenotypic information	skin pigmentation defects
References	Genome-wide, large-scale production of mutant mice by ENU mutagenesis.;Hrabé de Angelis M H, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R, ;2000;Nature genetics;25;444-7; 10932192 Genetics of dark skin in mice.;Fitch Karen R, McGowan Kelly A, van Raamsdonk Catherine D, Fuchs Helmut, Lee Daekee, Puech Anne, Hérault Yann, Threadgill David W, Hrabé de Angelis Martin, Barsh Gregory S, ;2003;Genes & development;17;214-28; 12533510 Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.;Fuchs H, Schughart K, Wolf E, Balling R, Hrabé de Angelis M, ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;528-30; 10886017

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Phakomatosis cesioflammea / Orphanet_79483
Phakomatosis cesiomarmorata / Orphanet_79484
Uveal melanoma / Orphanet_39044
Familial hypocalciuric hypercalcemia type 2 / Orphanet_101049
Autosomal dominant hypocalcemia / Orphanet_428

IMPC phenotypes (gene matching)

decreased circulating phosphate level / IMPC
decreased erythrocyte cell number / IMPC
decreased hemoglobin content / IMPC
decreased mean corpuscular volume / IMPC
decreased bone mineral density / IMPC
increased circulating alanine transaminase level / IMPC
increased circulating calcium level / IMPC
increased startle reflex / IMPC
increased red blood cell distribution width / IMPC
vertebral fusion / IMPC
decreased hematocrit / IMPC
increased bone mineral content / IMPC
abnormal behavior / IMPC
decreased circulating triglyceride level / IMPC
decreased circulating amylase level / IMPC
thrombocytopenia / IMPC

MGI phenotypes (allele matching)

increased foot pad pigmentation / MGI
hyperpigmentation / MGI
darkened coat color / MGI
increased tail pigmentation / MGI
increased ear pigmentation / MGI

MGI phenotypes (gene matching)

increased foot pad pigmentation / MGI
hyperpigmentation / MGI
increased circulating triglyceride level / MGI
hepatic steatosis / MGI
nervous system phenotype / MGI
darkened coat color / MGI
decreased susceptibility to type I hypersensitivity reaction / MGI
increased liver triglyceride level / MGI
increased tail pigmentation / MGI
increased ear pigmentation / MGI

Literature references

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.;Hrabé de Angelis M H, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R, ;2000;Nature genetics;25;444-7; 10932192
Genetics of dark skin in mice.;Fitch Karen R, McGowan Kelly A, van Raamsdonk Catherine D, Fuchs Helmut, Lee Daekee, Puech Anne, Hérault Yann, Threadgill David W, Hrabé de Angelis Martin, Barsh Gregory S, ;2003;Genes & development;17;214-28; 12533510
Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.;Fuchs H, Schughart K, Wolf E, Balling R, Hrabé de Angelis M, ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;528-30; 10886017

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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Legally binding conditions for the transfer

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C3HeB/FeJ-Gna11Mhdadsk7/Ieg