B6.Cg-Hic1^tm1.1Kori/Ph

Status	Available to order
EMMA ID	EM:06337
Citation information	RRID:IMSR_EM:06337 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.Cg-Hic1^tm1.1Kori/Ph
Alternative name	Hic1
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Hic1^tm1.1Kori
Gene/Transgene symbol	Hic1

Information from provider

Provider	Vladimir Korinek
Provider affiliation	Cell and Developmental Biology, Institute of Molecular Genetics of the ASCR, v. v. i.
Genetic information	An FRT-flanked flpe-neo cassette with a 5' loxP site was inserted downstream of exon 1. A loxP site was inserted downstream of the coding region of exon 2; flp-mediated recombination removed the flpe-neo cassette. The resulting modification is a conditional Hic1 null allele.
Phenotypic information	Homozygous mice have no obvious phenotype.
Breeding history	Backcrossed for 5 generations using C57BL/6ChR strain.
References	Generation of two modified mouse alleles of the Hic1 tumor suppressor gene.;Pospichalova Vendula, Tureckova Jolana, Fafilek Bohumil, Vojtechova Martina, Krausova Michaela, Lukas Jan, Sloncova Eva, Takacova Sylvia, Divoky Vladimir, Leprince Dominique, Plachy Jiri, Korinek Vladimir, ;2011;Genesis (New York, N.Y. : 2000);49;142-51; 21309068
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic
Animals used for archiving	homozygous males
Breeding at archiving centre	7 floxed/floxed males received, non-proven breeders. Started to mate them with C57BL/6N females. IVF started to freeze down 2-cell stage embryos.
Stage of embryos	2-cell

Disease and phenotype information

MGI phenotypes (gene matching)

small ears / MGI
lowered ear position / MGI
short snout / MGI
abnormal forelimb morphology / MGI
abnormal hindlimb morphology / MGI
abnormal brain development / MGI
exencephaly / MGI
dermatitis / MGI
increased metastatic potential / MGI
decreased embryo size / MGI
increased malignant tumor incidence / MGI
increased lung adenocarcinoma incidence / MGI
increased sarcoma incidence / MGI
increased carcinoma incidence / MGI
no abnormal phenotype detected / MGI
acrania / MGI
increased hepatocellular carcinoma incidence / MGI
abnormal ventral body wall morphology / MGI
abnormal palate morphology / MGI
abnormal craniofacial development / MGI
decreased fetal size / MGI
increased squamous cell carcinoma incidence / MGI
holoprosencephaly / MGI
abnormal brain dura mater morphology / MGI
increased pancreatic islet cell carcinoma incidence / MGI
perinatal lethality, complete penetrance / MGI
embryonic lethality during organogenesis, complete penetrance / MGI
increased lymphoma incidence / MGI

Literature references

Generation of two modified mouse alleles of the Hic1 tumor suppressor gene.;Pospichalova Vendula, Tureckova Jolana, Fafilek Bohumil, Vojtechova Martina, Krausova Michaela, Lukas Jan, Sloncova Eva, Takacova Sylvia, Divoky Vladimir, Leprince Dominique, Plachy Jiri, Korinek Vladimir, ;2011;Genesis (New York, N.Y. : 2000);49;142-51; 21309068

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
Not found what you were looking for? Search here for other strains available from EMMA.

Search

INFRAFRONTIER^® and European Mouse Mutant Archive - EMMA^® are registered trademarks at the European Union Intellectual Property Office (EUIPO).