MGI phenotypes (allele matching)
- embryonic lethality during organogenesis, complete penetrance / MGI
B6.Cg-Hic1tm2.1Kori/Ph
| Status | Available to order |
| EMMA ID | EM:06338 |
| Citation information | RRID:IMSR_EM:06338 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Hic1tm2.1Kori/Ph |
| Alternative name | Hic1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Hic1tm2.1Kori |
| Gene/Transgene symbol | Hic1 |
Information from provider
| Provider | Vladimir Korinek |
| Provider affiliation | Cell and Developmental Biology, Institute of Molecular Genetics of the ASCR, v. v. i. |
| Genetic information | An FRT-flanked flpe-neo cassette was inserted upstream of exon 2. Most of exon 2 was replaced with a citrine gene; flp-mediated recombination removed the flpe-neo cassette. Hic1-citrine reporter mice can be used to monitor the activity of the Hic1 locus using citrine fluorescence. |
| Phenotypic information | Complete embryonic lethality of homozygous mice during organogenesis; mice die around E9.5. Heterozygous mice are viable and can be used to monitor the activity of the Hic1 locus using citrine fluorescence. |
| Breeding history | Backcrossed for 5 generations using C57BL/6ChR strain. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
| Animals used for archiving | heterozygous males, wild-type females |
| Breeding at archiving centre | First 3 males received and put into breeding with C57BL/6N partners, since they have not been in breeding before. |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- small ears / MGI
- lowered ear position / MGI
- short snout / MGI
- abnormal forelimb morphology / MGI
- abnormal hindlimb morphology / MGI
- abnormal brain development / MGI
- exencephaly / MGI
- dermatitis / MGI
- increased metastatic potential / MGI
- decreased embryo size / MGI
- increased malignant tumor incidence / MGI
- increased lung adenocarcinoma incidence / MGI
- increased sarcoma incidence / MGI
- increased carcinoma incidence / MGI
- no abnormal phenotype detected / MGI
- acrania / MGI
- increased hepatocellular carcinoma incidence / MGI
- abnormal ventral body wall morphology / MGI
- abnormal palate morphology / MGI
- abnormal craniofacial development / MGI
- decreased fetal size / MGI
- increased squamous cell carcinoma incidence / MGI
- holoprosencephaly / MGI
- abnormal brain dura mater morphology / MGI
- increased pancreatic islet cell carcinoma incidence / MGI
- perinatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- increased lymphoma incidence / MGI
Literature references
- Generation of two modified mouse alleles of the Hic1 tumor suppressor gene.;Pospichalova Vendula, Tureckova Jolana, Fafilek Bohumil, Vojtechova Martina, Krausova Michaela, Lukas Jan, Sloncova Eva, Takacova Sylvia, Divoky Vladimir, Leprince Dominique, Plachy Jiri, Korinek Vladimir, ;2011;Genesis (New York, N.Y. : 2000);49;142-51; 21309068