MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
B6.129S2-Synbtm1.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:06348 |
| Citation information | RRID:IMSR_EM:06348 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2-Synbtm1.1Ics/Ics |
| Alternative name | Syncytin-B conditional KO |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Synbtm1.1Ics |
| Gene/Transgene symbol | Synb |
Information from provider
| Provider | Thierry Heidmann |
| Provider affiliation | UMR8122 CNRS, Institut Gustavec Roussy |
| Genetic information | In the targeting vector, the syncytin-B ORF and its surrounding sequences were amplified from 129/Sv mouse DNA by PCR. The targeted allele contains the unique syncytin-B ORF flanked by loxP recombination sites allowing its conditional excision. |
| Phenotypic information | Mice with conditional allele: no obvious phenotypic defects. Mice with syncytin-B knock-out allele (after cre-mediated excision of syncytin-B ORF): homozygous null embryos display an impaired placentation, with late-onset growth retardation and reduced neonate number. |
| Breeding history | Backcrossed 5 times to C57BL/6. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
| Animals used for archiving | heterozygous males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased body weight / MGI
- abnormal placenta labyrinth morphology / MGI
- postnatal growth retardation / MGI
- no phenotypic analysis / MGI
- fetal growth retardation / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- decreased fetal weight / MGI
- preweaning lethality, incomplete penetrance / MGI
- abnormal syncytiotrophoblast morphology / MGI
Literature references
- A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast.;Dupressoir Anne, Vernochet Cécile, Harper Francis, Guégan Justine, Dessen Philippe, Pierron Gérard, Heidmann Thierry, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;E1164-73; 22032925