IMPC phenotypes (gene matching)
C3H;C-Gsdma3Fgn/H
| Status | Available to order |
| EMMA ID | EM:00067 |
| Citation information | RRID:IMSR_EM:00067 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3H;C-Gsdma3Fgn/H |
| Alternative name | Fgn, finnegan |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Gsdma3Fgn |
| Gene/Transgene symbol | Gsdma3 |
Information from provider
| Provider | Pat Nolan |
| Provider affiliation | MRC Mammalian Genetics Unit |
| Genetic information | The Finnegan stock arose following the screening of ENU mutagenised BALB/c males. The Finnegan mutation has been identified as a point mutation T278P in gasdermin 3 (Gsdm3), a gene of unknown function. |
| Phenotypic information | Mice carrying this mutation show progressive hair loss. Weanlings show a typical ragged coat phenotype. Following this mice go through several cycles of hair loss and regrowth. Adult mice eventually become almost hairless with a small amount of hair around the snout. |
| References |
|
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- big ears / MGI
- decreased hair follicle number / MGI
- abnormal guard hair morphology / MGI
- alopecia / MGI
- sparse hair / MGI
- delayed hair regrowth / MGI
- abnormal hair cycle / MGI
- absent sebaceous gland / MGI
- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- enlarged thymus / MGI
- abnormal skin condition / MGI
- dermatitis / MGI
- thick skin / MGI
- wrinkled skin / MGI
- skin lesions / MGI
- abnormal epidermal layer morphology / MGI
- thick epidermis / MGI
- epidermal hyperplasia / MGI
- hyperkeratosis / MGI
- microphthalmia / MGI
- corneal opacity / MGI
- abnormal coat appearance / MGI
- acanthosis / MGI
- abnormal skin morphology / MGI
- abnormal hair growth / MGI
- coarse hair / MGI
- long hair / MGI
- abnormal corneal stroma development / MGI
- abnormal hair follicle development / MGI
- abnormal hair cuticle / MGI
- dry skin / MGI
- skin inflammation / MGI
- reproductive system phenotype / MGI
- abnormal skin physiology / MGI
- abnormal corneal epithelium morphology / MGI
- abnormal hair cycle anagen phase / MGI
- abnormal hair cycle catagen phase / MGI
- progressive hair loss / MGI
- thin hair shaft / MGI
- hypergranulosis / MGI
- increased corneal stroma thickness / MGI
- abnormal hair follicle bulge morphology / MGI
- eye opacity / MGI
- abnormal skin adnexa morphology / MGI
- integument phenotype / MGI
- decreased alkaline phosphatase activity / MGI
- disorganized corneal epithelium / MGI
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191