| Status | Available to order |
| EMMA ID | EM:06735 |
| Citation information | RRID:IMSR_EM:06735 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Crhr1tm1Wrst/Ieg |
| Alternative name | Crhr1-ko (Crhr1tm1Wrst) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Crhr1tm1Wrst |
| Gene/Transgene symbol | Crhr1 |
| Provider | Jan Deussing |
| Provider affiliation | Molecular Neurogenetics, Max Planck Institute of Psychiatry |
| Genetic information | A neomycin resistance cassette replaced a 3.1 kb genomic fragment containing sequences encoding transmembrane domains 4-7, including the G-coupling protein domain and the intracellular cytoplasmic tail. |
| Phenotypic information | Homozygous mutant mice show a chronic corticosterone deficit due to impaired basal and stress-induced activity of the hypothalamic-pituitary-adrenal axis (HPA). Moreover, homozygous mutant mice show reduced anxiety-related behaviour. Homozygous mutant mice show reduced viability (up to 90% die after weaning in mice backcrossed to C57BL/6N background). Pups can survive if the mother is not homozygous for the mutation and can pass on enough corticosteroids to the pups. Homozygotes that survive after weaning are fertile. |
| Breeding history | Currently backcrossed to C57BL/6N (N=4). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6N males |
