IMPC phenotypes (gene matching)
B6.129P2-Ucn3tm1.1Jde/Ieg
| Status | Available to order |
| EMMA ID | EM:06736 |
| Citation information | RRID:IMSR_EM:06736 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Ucn3tm1.1Jde/Ieg |
| Alternative name | Ucn3-ko (Ucn3tm1.1Jde) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ucn3tm1.1Jde |
| Gene/Transgene symbol | Ucn3 |
Information from provider
| Provider | Jan Deussing |
| Provider affiliation | Molecular Neurogenetics, Max Planck Institute of Psychiatry |
| Genetic information | A 3.6 kb fragment including exon which encodes for the entire open reading frame was replaced with a tau-lacZ reporter and a self-excising neo cassette via homologous recombination. In situ hybridization confirmed the absence of transcript in brains from homozygous mice. X-gal staining confirmed that lacZ expression recapitulated endogenous gene expression. |
| Phenotypic information | Homozygous mutant mice show improved social discrimination abilities. |
| Breeding history | Currently backcrossed to C57BL/6N (N=10). |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | homozygous C57BL/6N males |
Disease and phenotype information
Literature references
- Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids.;Müller M B, Landgraf R, Preil J, Sillaber I, Kresse A E, Keck M E, Zimmermann S, Holsboer F, Wurst W, ;2000;Endocrinology;141;4262-9; 11089561
- Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors.;Sillaber Inge, Rammes Gerhard, Zimmermann Stephan, Mahal Beatrice, Zieglgänsberger Walter, Wurst Wolfgang, Holsboer Florian, Spanagel Rainer, ;2002;Science (New York, N.Y.);296;931-3; 11988580
- Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus.;Chen Yuncai, Bender Roland A, Brunson Kristen L, Pomper Jörn K, Grigoriadis Dimitri E, Wurst Wolfgang, Baram Tallie Z, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;15782-7; 15496472
- Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity.;Deussing Jan M, Kühne Claudia, Pütz Benno, Panhuysen Markus, Breu Johannes, Stenzel-Poore Mary P, Holsboer Florian, Wurst Wolfgang, ;2007;Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism;27;1476-95; 17293846
- Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity.;Schierloh Anja, Deussing Jan, Wurst Wolfgang, Zieglgänsberger Walter, Rammes Gerhard, ;2007;Neuroscience letters;416;82-6; 17316992
- Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele.;Kühne Claudia, Puk Oliver, Graw Jochen, Hrabě de Angelis Martin, Schütz Günther, Wurst Wolfgang, Deussing Jan M, ;2012;The Journal of comparative neurology;520;3150-80; 22886732