MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
C57BL/6-Mgat5btm1Itl/Cnbc
| Status | Available to order |
| EMMA ID | EM:06748 |
| Citation information | RRID:IMSR_EM:06748 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Mgat5btm1Itl/Cnbc |
| Alternative name | C57BL/6-GnT-Vb floxed |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Mgat5btm1Itl |
| Gene/Transgene symbol | Mgat5b |
Information from provider
| Provider | Michael Pierce |
| Provider affiliation | Complex Carbohydrate Research Center, University of Georgia |
| Genetic information | C57BL/6-GnT-Vb conditional knock-out mutation. Exon 6 was floxed. |
| Phenotypic information | In the brain, a dramatic reduction in 1,6-branched O-mannosyl structures. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- demyelination / MGI
- seminiferous tubule degeneration / MGI
- abnormal homeostasis / MGI
- brain inflammation / MGI
- abnormal bone marrow morphology / MGI
- no phenotypic analysis / MGI
- astrocytosis / MGI
- decreased susceptibility to injury / MGI
- increased circulating glucose level / MGI
- decreased pre-B cell number / MGI
- increased IgG2b level / MGI
- abnormal renal tubule epithelium morphology / MGI
- increased oligodendrocyte number / MGI
- enhanced humoral immune response / MGI
Literature references
- Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V.;Lee Jin Kyu, Matthews Russell T, Lim Jae-Min, Swanier Kiara, Wells Lance, Pierce J Michael, ;2012;The Journal of biological chemistry;287;28526-36; 22715095