| Status | Available to order |
| EMMA ID | EM:06786 |
| Citation information | RRID:IMSR_EM:06786 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Mmp19tm1Rase/Ph |
| Alternative name | B6.MMP19 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mmp19tm1Rase |
| Gene/Transgene symbol | Mmp19 |
| Provider | Radislav Sedlacek |
| Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
| Genetic information | A targeting construct based on pPNT vector was generated by replacement of 1088 bp region of MMP19 gene spanning the end of exon 3 and the whole exon 4 encoding the catalytic domain by the neomycin resistance cassette. |
| Phenotypic information | a) MMP19-/- mice show reduced inflammatory reactions in the skin. Immature knockout mice have delayed development of thymocyte. b) MMP-19-deficiency reduces the extent of hepatocellular injury and leads to faster recovery from liver fibrosis. |
| Breeding history | The strain is kept on C57BL/6NCrl background and backcrossed more than 20 generations. wt x het, het x het and ko x ko matings are currently done. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
| Animals used for archiving | homozygous males, wild-type females |
| Stage of embryos | 2-cell |
Orphanet associated rare diseases, based on orthologous gene matching
