IMPC phenotypes (allele matching)
B6.129-Kcnk3tm1Sgb Dkk3tm1Cni/Orl
| Status | Available to order |
| EMMA ID | EM:06895 |
| Citation information | RRID:IMSR_EM:06895 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Kcnk3tm1Sgb Dkk3tm1Cni/Orl |
| Alternative name | Kcnk3/Dkk3 KO mice |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Kcnk3tm1Sgb, Dkk3tm1Cni |
| Gene/Transgene symbol | Kcnk3, Dkk3 |
Information from provider
| Provider | Enzo Lalli |
| Provider affiliation | Institut de Pharmacologie Moleculaire et Cellulaire, CNRS |
| Additional owner | Dr. Wisden (Kcnk3 null mouse) and Dr. Niehrs (Dkk3 null mice) |
| Genetic information | Kcnk3/Dkk3 double KO mice. |
| Phenotypic information | Low-renin hyperaldosteronism in both male and female sex. |
| Breeding history | Dkk3 KO mice were crossed with Kcnk3 KO mice and then backcrossed to C57BL/6 mice for more than 15 generations. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Heritable pulmonary arterial hypertension / Orphanet_275777
MGI phenotypes (allele matching)
- hyperactivity / MGI
- increased IgM level / MGI
- increased mean corpuscular volume / MGI
- increased hematocrit / MGI
- increased circulating aldosterone level / MGI
- increased mean corpuscular hemoglobin / MGI
- increased hemoglobin content / MGI
- decreased NK cell number / MGI
- abnormal motor coordination/ balance / MGI
MGI phenotypes (gene matching)
- hyperactivity / MGI
- increased IgM level / MGI
- increased mean corpuscular volume / MGI
- increased hematocrit / MGI
- increased circulating aldosterone level / MGI
- increased mean corpuscular hemoglobin / MGI
- increased hemoglobin content / MGI
- decreased NK cell number / MGI
- abnormal motor coordination/balance / MGI
- no abnormal phenotype detected / MGI
- increased circulating aldosterone level / MGI
- no phenotypic analysis / MGI
- nervous system phenotype / MGI
- respiratory system phenotype / MGI
- abnormal action potential / MGI
Literature references
- Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex.;El Wakil Abeer, Bandulik Sascha, Guy Nicolas, Bendahhou Saïd, Zennaro Maria-Christina, Niehrs Christof, Mari Bernard, Warth Richard, Barhanin Jacques, Lalli Enzo, ;2012;Human molecular genetics;21;4922-9; 22918120