| Status | Available to order |
| EMMA ID | EM:06916 |
| Citation information | RRID:IMSR_EM:06916 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2(Cg)-Tbc1d10ctm1.1Psou/Orl |
| Alternative name | Carabin flox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Tbc1d10ctm1.1Psou |
| Gene/Transgene symbol | Tbc1d10c |
| Provider | Pauline Soulas-Sprauel |
| Provider affiliation | CRBS (Centre de Recherche en Biomédecine), Inserm UMR 1109 (Immuno-Rhumatologie Moléculaire, IRM) |
| Genetic information | Carabin conditional KO mice: exons 3 and 4 floxed mice (see reference Schickel JN et coll, 2012, EMBO Mol Med, PMID: 23109291) |
| Phenotypic information | Increased B cell response in vitro and in vivo. Development of autoantibodies and glomerulonephritis after CpGDNA (TLR9 agonist) injection, in vivo, in complete KO mice and B cell conditional KO mice (see reference Schickel JN et coll, 2012, EMBO Mol Med, PMID: 23109291) |
| Breeding history | 9 backcrosses to C57BL/6 mice. Currently backcrossed to C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males |
