MGI phenotypes (allele matching)
- increased body weight / MGI
C3HeB/FeJ-Mc4rMhdahwe13/Ieg
| Status | Available to order |
| EMMA ID | EM:06969 |
| Citation information | RRID:IMSR_EM:06969 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3HeB/FeJ-Mc4rMhdahwe13/Ieg |
| Alternative name | HWE013Mc4rL54QMhda |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Mc4rMhdahwe13 |
| Gene/Transgene symbol | Mc4r |
Information from provider
| Provider | Sibylle Sabrautzki |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | Missense mutation c.161A to T, p.Leu54Gln. |
| Phenotypic information | Mutant mice show very high body weight; mutant female mice show body weights of 38-47g, mutant male mice of 42-48g. |
| Breeding history | Dominant mouse line, phenotype outcrossed more than 10 generations. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Obesity due to melanocortin 4 receptor deficiency / Orphanet_71529
MGI phenotypes (gene matching)
- increased body length / MGI
- increased body weight / MGI
- obese / MGI
- decreased body weight / MGI
- increased body size / MGI
- polyphagia / MGI
- increased circulating free fatty acid level / MGI
- hyperglycemia / MGI
- liver inflammation / MGI
- reduced fertility / MGI
- abnormal glucose homeostasis / MGI
- increased circulating insulin level / MGI
- hepatic steatosis / MGI
- increased circulating alanine transaminase level / MGI
- increased liver weight / MGI
- no phenotypic analysis / MGI
- abnormal locomotor activation / MGI
- increased hepatocellular carcinoma incidence / MGI
- liver fibrosis / MGI
- increased lean body mass / MGI
- decreased lean body mass / MGI
- increased energy expenditure / MGI
- decreased adiponectin level / MGI
- decreased osteoclast cell number / MGI
- abnormal oxygen consumption / MGI
- decreased oxygen consumption / MGI
- impaired glucose tolerance / MGI
- homeostasis/metabolism phenotype / MGI
- abnormal food intake / MGI
- increased susceptibility to weight gain / MGI
- increased percent body fat/body weight / MGI
- increased bone mass / MGI
- increased susceptibility to diet-induced obesity / MGI
- increased circulating leptin level / MGI
- increased body mass index / MGI
- increased circulating interleukin-6 level / MGI
- increased abdominal fat pad weight / MGI
- increased liver triglyceride level / MGI
- increased total body fat amount / MGI
- adipose tissue inflammation / MGI
- abnormal circadian behavior phase / MGI