C57BL/6-Slc2a9tm1.2Thor/Biat

Status

Available to order

EMMA IDEM:06970
Citation informationRRID:IMSR_EM:06970 

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International strain nameC57BL/6-Slc2a9tm1.2Thor/Biat
Alternative nameSLC2A9-/- (Glut9KO); ILAR name: B6-Tgh(SLC2a9 L-)CIG
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolSlc2a9tm1.2Thor
Gene/Transgene symbolSlc2a9

Information from provider

ProviderFrederic Preitner
Provider affiliationCenter for Integrative Genomics, University of Lausanne
Genetic informationTargeting vector with exon 4 flanked by loxP sites. Within loxP sites, neo selection marker is flanked by frt sites. After homologous recombination, neo selection marker removed in vivo by transgenic expression of flippase to generate conditional knock-out. Constitutive knock-out (whole-body) generated by Gt(ROSA)26Sor-cre-mediated deletion of exon 4. Deletion of exon 4 results in loss of function by generating a frameshift. The Gt(ROSA)26Sor-cre allele and flippase transgene were bred out by cross to wild-type C57BL/6J mice.
Phenotypic informationHeterozygous: no phenotype. Homozygous: hyperuricemia, hyperuricosuria, urate nephropathy.
Breeding historyBred heterozygous x heterozygous
References
  • Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.;Preitner Frédéric, Bonny Olivier, Laverrière Alexandra, Rotman Samuel, Firsov Dmitri, Da Costa Anabela, Metref Salima, Thorens Bernard, ;2009;Proceedings of the National Academy of Sciences of the United States of America;106;15501-6; 19706426
Homozygous fertilenot known
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • increased urine sodium level / MGI
  • increased circulating magnesium level / MGI
  • hydronephrosis / MGI
  • kidney cortex cysts / MGI
  • decreased body weight / MGI
  • polydipsia / MGI
  • polyuria / MGI
  • kidney inflammation / MGI
  • dilated renal tubules / MGI
  • nephrolithiasis / MGI
  • decreased urine osmolality / MGI
  • renal interstitial fibrosis / MGI
  • increased circulating creatinine level / MGI
  • increased urine potassium level / MGI
  • increased blood uric acid level / MGI
  • decreased urine pH / MGI
  • abnormal renal reabsorbtion / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • renal tubule atrophy / MGI
  • tubulointerstitial nephritis / MGI
  • kidney cortex atrophy / MGI
  • increased urine magnesium level / MGI
  • uraturia / MGI
MGI phenotypes (gene matching)
  • hydronephrosis / MGI
  • kidney cortex cysts / MGI
  • decreased body weight / MGI
  • polydipsia / MGI
  • polyuria / MGI
  • kidney inflammation / MGI
  • no abnormal phenotype detected / MGI
  • dilated renal tubules / MGI
  • nephrolithiasis / MGI
  • decreased urine osmolality / MGI
  • renal interstitial fibrosis / MGI
  • increased circulating creatinine level / MGI
  • increased urine potassium level / MGI
  • increased urine sodium level / MGI
  • increased blood uric acid level / MGI
  • decreased urine pH / MGI
  • increased circulating magnesium level / MGI
  • abnormal renal reabsorbtion / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • renal tubule atrophy / MGI
  • tubulointerstitial nephritis / MGI
  • kidney cortex atrophy / MGI
  • increased urine magnesium level / MGI
  • uraturia / MGI

Literature references

  • Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.;Preitner Frédéric, Bonny Olivier, Laverrière Alexandra, Rotman Samuel, Firsov Dmitri, Da Costa Anabela, Metref Salima, Thorens Bernard, ;2009;Proceedings of the National Academy of Sciences of the United States of America;106;15501-6; 19706426

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

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Legally binding conditions for the transfer

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