MGI phenotypes (allele matching)
129(B6)-Thy1tm1Rjmo/H
| Status | Available to order |
| EMMA ID | EM:07002 |
| Citation information | RRID:IMSR_EM:07002 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129(B6)-Thy1tm1Rjmo/H |
| Alternative name | Thy-1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Thy1tm1Rjmo |
| Gene/Transgene symbol | Thy1 |
Information from provider
| Provider | Roger Morris |
| Provider affiliation | School of Biomedical Science, King's College London |
| Genetic information | The insertion of a neomycin resistance cassette disrupted the codon for the third amino acid of the mature protein, located in the third exon. Immunoblotting and immunohistochemistry were both unable to detect protein in mutants. |
| Phenotypic information | Nervous system: reduced long term potentiation (PubMed ID: 8587606). Strong inhibition of LTP in the dentate gyrus but not in CA1, however spatial learning as assessed in the water-maze is unimpaired. Respiratory system: pulmonary fibrosis (PubMed ID: 16049324). Marked increase in severity of lung fibrosis and more extensive collagen deposition in response to intra-tracheal bleomycin, compared to controls. |
| Breeding history | Gene targeted in 129/SvEv stem cells, offspring outbred to C57BL/6J mice, then backcrossed for 4 generations onto 129/SvEv before being maintained by interbreeding. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1.;Nosten-Bertrand M, Errington M L, Murphy K P, Tokugawa Y, Barboni E, Kozlova E, Michalovich D, Morris R G, Silver J, Stewart C L, Bliss T V, Morris R J, ;1996;Nature;379;826-9; 8587606
- Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis.;Hagood James S, Prabhakaran Priya, Kumbla Pallavi, Salazar Lorena, MacEwen Mark W, Barker Thomas H, Ortiz Luis A, Schoeb Trenton, Siegal Gene P, Alexander C Bruce, Pardo Annie, Selman Moisés, ;2005;The American journal of pathology;167;365-79; 16049324